5-Fluoro-2,4-dimethoxyphenol

Base Information

• Chemical Name: 5-Fluoro-2,4-dimethoxyphenol
• CAS No.: 1065076-49-4
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.167
• Hs Code.: 2914700090
• Mol file: 1065076-49-4.mol

Synonyms:5-Fluoro-2,4-dimethoxyphenol;1-(2-Fluoro-4-hydroxy-5-methoxyphenyl)ethanone

Chemical Property of 5-Fluoro-2,4-dimethoxyphenol

Chemical Property:

• Boiling Point: 326℃
• PKA: 7.20±0.23(Predicted)
• Flash Point: 151℃
• PSA: 38.69000
• Density: 1.247
• LogP: 1.54850
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Fluoro-4''-hydroxy-5''-methoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2''-Fluoro-4''-hydroxy-5''-methoxyacetophenone

Technology Process of 5-Fluoro-2,4-dimethoxyphenol

There total 1 articles about 5-Fluoro-2,4-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-fluoro-2-methoxy phenol (72955-97-6) + acetyl chloride (75-36-5) → 1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethanone (1065076-49-4)

Guidance literature:

acetyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; for 0.166667h;

5-fluoro-2-methoxy phenol; In 1,2-dichloro-ethane; at 40 ℃;

Reference yield: 97.0%

1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethanone (1065076-49-4) → 4-ethyl-5-fluoroguaiacol (1065076-45-0)

Guidance literature:

With acetic acid; zinc; at 70 ℃; Product distribution / selectivity; Reflux;

Reference yield:

1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethanone (1065076-49-4) → 4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile (1269055-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; acetic acid / 70 °C / Reflux

2: potassium hydroxide / acetonitrile / 16 h / Reflux; Inert atmosphere

With acetic acid; potassium hydroxide; zinc; In acetonitrile; 1: Clemmensen Reaction;

upstream raw materials:

5-fluoro-2-methoxy phenol

acetyl chloride

Downstream raw materials:

4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile

4-(4-ethyl-5-fluoro-2-methoxy-phenoxy)-3-fluorobenzamide

4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide

4-ethyl-5-fluoroguaiacol

Refernces

• 1、 -. "NOVEL ANTIBACTERIAL HYDROXYPHENYL COMPOUND". Page/Page column 13-14. . Retrieved 2011/04/14.