1-Acetyl-4-benzylpiperazine

Base Information

• Chemical Name: 1-Acetyl-4-benzylpiperazine
• CAS No.: 208924-94-1
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.299
• Nikkaji Number: J965.284A
• Mol file: 208924-94-1.mol

Synonyms:1-Acetyl-4-benzylpiperazine;Benzylpiperazine, AC;1-(4-Benzyl-piperazin-1-yl)ethanone;208924-94-1;CBMicro_020411;1-(4-benzylpiperazin-1-yl)ethanone;Oprea1_457563;SCHEMBL1943497;Methyl(4-benzylpiperazino) ketone;CCG-8232;AKOS003861686;BIM-0020206.P001

Chemical Property of 1-Acetyl-4-benzylpiperazine

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 228

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N1CCN(CC1)CC2=CC=CC=C2

Technology Process of 1-Acetyl-4-benzylpiperazine

There total 5 articles about 1-Acetyl-4-benzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethylpiperazine (2759-28-6) + acetyl chloride (75-36-5) → 1-(4-benzylpiperazin-1-yl)ethan-1-one (208924-94-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2004.10.008

Reference yield:

[4-(4-Benzyl-piperazin-1-ylmethyl)-phenyl]-dimethyl-amine → 1-(4-benzylpiperazin-1-yl)ethan-1-one (208924-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: 1 N NaOH / methanol

With triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(98)00584-X

Reference yield:

1-(phenylmethyl)-4-[(4'-methoxyphenyl)methyl]piperazine (148120-38-1) → 1-(4-benzylpiperazin-1-yl)ethan-1-one (208924-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: 1 N NaOH / methanol

With triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(98)00584-X

upstream raw materials:

1-phenylmethylpiperazine

acetyl chloride

N-trifluoroacetyl,N-benzyl piperazine

1-(phenylmethyl)-4-[(4'-methoxyphenyl)methyl]piperazine

Downstream raw materials:

2-[1-(4-Benzyl-piperazin-1-yl)-eth-(E)-ylideneamino]-4,5-dimethoxy-benzonitrile

N-acetylpiperidine

4-Amino-6,7-dimethoxy-2-(4-benzylpiperazin-1-yl)quinoline

1-benzyl-4-(tert-butyl)piperazine