(R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate
• CAS No.: 1064051-97-3
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Mol file: 1064051-97-3.mol

Synonyms:(R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate;tert-butyl N-Methyl-N-[(3R)-pyrrolidin-3-ylMethyl]carbaMate;N-Methyl-N-[(3R)-3-pyrrolidinylmethyl]carbamic acid tert-butyl ester

Chemical Property of (R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate

Chemical Property:

• Boiling Point: 287℃
• Flash Point: 127℃
• PSA: 41.57000
• Density: 0.993
• LogP: 1.79160

Purity/Quality:

98%min ^*data from raw suppliers

(R)-TERT-BUTYL METHYL(PYRROLIDIN-3-YLMETHYL)CARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate

There total 1 articles about (R)-tert-butyl methyl(pyrrolidin-3-ylmethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-3-[N-(tert-butoxycarbonyl)-N-methyl]aminomethylpyrrolidine (1064051-97-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 - 25 ℃; for 15h;

Reference yield: 68.0%

(R)-3-[N-(tert-butoxycarbonyl)-N-methyl]aminomethylpyrrolidine (1064051-97-3) + 1-([1,1'-biphenyl]-4-ylmethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → (S)-1-([1,1'-biphenyl]-4-ylmethyl)-6-fluoro-7-(3-((methylamino)methyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:

(R)-3-[N-(tert-butoxycarbonyl)-N-methyl]aminomethylpyrrolidine; 1-([1,1'-biphenyl]-4-ylmethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 40 ℃; for 24h;

With hydrogenchloride; In water; dimethyl sulfoxide; at 25 ℃; for 24h;

DOI:10.1016/j.ejmech.2019.03.040

Reference yield: 50.0%

(R)-3-[N-(tert-butoxycarbonyl)-N-methyl]aminomethylpyrrolidine (1064051-97-3) + 1-(4-(1H-pyrazol-1-yl)benzyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → (S)-1-(4-(1H-pyrazol-1-yl)benzyl)-6-fluoro-7-(3-((methylamino)methyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:

(R)-3-[N-(tert-butoxycarbonyl)-N-methyl]aminomethylpyrrolidine; 1-(4-(1H-pyrazol-1-yl)benzyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With triethylamine; In dimethyl sulfoxide; at 40 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In water; dimethyl sulfoxide; acetonitrile; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.03.040

Refernces

• 1、 -. "QUINAZOLINEDIONE DERIVATIVE". Paragraph 1628; 1631; 1634; 1635. . Retrieved 2015/03/16.