Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride
• CAS No.: 1208361-39-0
• Molecular Formula: C6H7BrN2O2
• Molecular Weight: 219.03598
• Hs Code.: 2933990090
• Mol file: 1208361-39-0.mol

Synonyms:Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride;1-Amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester;Methyl 1-aMino-4-broMo-1H-pyrrole-2-carboxylate

Chemical Property of Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride

Chemical Property:

• PSA: 57.25000
• LogP: 1.33220
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl1-amino-4-bromo-1H-pyrrole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride

There total 8 articles about Methyl 4-broMo-1-aMinopyrrole-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

methyl 4-bromo-1H-pyrrole-2-carboxylate (934-05-4) → 1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester (1208361-39-0)

Guidance literature:

methyl 4-bromo-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

With N-(2,4-dinitrophenyl)hydroxylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 77.0%

O-(diphenylphosphinyl)hydroxylamine (72804-96-7) + methyl 4-bromo-1H-pyrrole-2-carboxylate (934-05-4) → 1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester (1208361-39-0)

Guidance literature:

methyl 4-bromo-1H-pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

O-(diphenylphosphinyl)hydroxylamine; In N,N-dimethyl-formamide; for 1h;

Reference yield: 38.2%

diphenyl (aminooxy)phosphonate (88088-31-7) + methyl 4-bromo-1H-pyrrole-2-carboxylate (934-05-4) → 1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester (1208361-39-0)

Guidance literature:

methyl 4-bromo-1H-pyrrole-2-carboxylate; With lithium hexamethyldisilazane; In N,N-dimethyl-formamide; at -10 ℃; for 0.25h;

diphenyl (aminooxy)phosphonate; at 20 ℃; for 15h;

upstream raw materials:

methyl 4-bromo-1H-pyrrole-2-carboxylate

O-(diphenylphosphinyl)hydroxylamine

pyrrol-2-yl trichloromethyl ketone

1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroethanone

Downstream raw materials:

6-(5-chloropyridin-2-yl)-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

6-(5-chloropyridin-2-yl)-3-[4-(3-hydroxy-pyrrolidin-1-yl)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

6-(5-chloropyridin-2-yl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

6-(5-chloropyrimidin-2-yl)-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Refernces

• 1、 -. "DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS". Paragraph 000563. . Retrieved 2019/11/04.
• 2、 -. "Dipeptidyl peptidase - IV inhibitor, use thereof and intermediate and intermediate preparation method". Paragraph 0086-0089. . Retrieved 2018/07/30.