Olmesartan-d4

Base Information

Chemical Name:Olmesartan-d4
CAS No.:1420880-41-6
Molecular Formula:C24H22N6O3D4
Molecular Weight:450.526287112
Hs Code.:
Mol file:1420880-41-6.mol

Synonyms:Olmesartan-d4

Suppliers and Price of Olmesartan-d4

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Olmesartan-d4Acid
1mg
$ 145.00

TRC
Olmesartan-d4Acid
10mg
$ 1175.00

American Custom Chemicals Corporation
OLMESARTAN-D4 95.00%
5MG
$ 498.15

Total 8 raw suppliers

Chemical Property of Olmesartan-d4

Chemical Property:

PSA：129.81000
LogP:3.65660

Purity/Quality:

97% ^*data from raw suppliers

Olmesartan-d4Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Labelled Olmesartan Acid (O550001). Olmesartan Acid is an angiotensin II receptor antagonist. Olmesartan Acid is used as an anti-hypertensive.

Technology Process of Olmesartan-d4

There total 6 articles about Olmesartan-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

: 1420880-40-5
ethyl 1-((2,3,5,6-tetra-[²H]-2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

: 1420880-41-6
C₂₄H₂₂⁽²⁾H₄N₆O₃

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; at 20 ℃; for 4.5h;
DOI:10.1002/jlcr.2956

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 1420880-41-6
C₂₄H₂₂⁽²⁾H₄N₆O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: toluene / 16 h / Reflux

4.1: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Cooling with ice

6.2: 2.5 h / 20 °C

7.1: acetic acid / 5 h / 20 - 80 °C

8.1: lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 °C

With pyridine; N-Bromosuccinimide; lithium hydroxide monohydrate; potassium tert-butylate; iodine; magnesium; acetic acid; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: |Grignard Reaction;
DOI:10.1002/jlcr.2956

Reference yield:

: 112484-85-2
2,3,5,6-tetra-[²H]-4-bromo toluene

: 1420880-41-6
C₂₄H₂₂⁽²⁾H₄N₆O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: toluene / 16 h / Reflux

4.1: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Cooling with ice

6.2: 2.5 h / 20 °C

7.1: acetic acid / 5 h / 20 - 80 °C

8.1: lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 °C

With pyridine; N-Bromosuccinimide; lithium hydroxide monohydrate; potassium tert-butylate; iodine; magnesium; acetic acid; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: |Grignard Reaction;
DOI:10.1002/jlcr.2956