112484-85-2

Basic information

• Product Name: 4-BROMOTOLUENE-2,3,5,6-D4
• Synonyms: 4-BROMOTOLUENE-2,3,5,6-D4;4-BroMotoluene--d4
• CAS NO: 112484-85-2
• Molecular Formula: C₇H₇Br
• Molecular Weight: 175.06
• Mol File: 112484-85-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BROMOTOLUENE-2,3,5,6-D4(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOTOLUENE-2,3,5,6-D4(112484-85-2)
• EPA Substance Registry System: 4-BROMOTOLUENE-2,3,5,6-D4(112484-85-2)

Safety Data

• Hazardous Substances Data: 112484-85-2(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 

Downstream Products

• 1330277-14-9 5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole 
• 1420880-38-1 5-(2',3',5',6'-tetra-[²H]-4'-methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 
• 1420880-37-0 5-(2',3',5',6'-tetra-[²H]-4'-methylbiphenyl-2-yl)-1H-tetrazole 
• 1346604-70-3 C₂₄H₁₆⁽²⁾H₄N₆O₃ 
• 1420880-47-2 ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo [d]imidazole-7-carboxylate 
• 1420880-46-1 ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate 
• 1420880-45-0 ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate 
• 1420880-44-9 ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate 
• 1420880-43-8 ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate 
• 1420880-41-6 C₂₄H₂₂⁽²⁾H₄N₆O₃ 
• 1420880-40-5 ethyl 1-((2,3,5,6-tetra-[²H]-2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 
• 1420880-39-2 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate 
• 1027088-37-4 C₁₈H₁₄⁽²⁾H₄N₆O₄S 
• 1027088-35-2 C₁₉H₁₄⁽²⁾H₄O₅N₄S 

Relevant articles and documents

Synthesis of Multideuterated (Hetero)aryl Bromides by Ag(I)-Catalyzed H/D Exchange

Deterium-labeled (hetero)aryl bromide is one of the most widespread applicable motifs to achieve important deuterated architectures for various scientific applications. Traditionally, these deterium-labeled (hetero)aryl bromides are commonly prepared via multistep syntheses. Herein, we disclose a direct H/D exchange protocol for deuteration of (hetero)aryl bromides using Ag2CO3 as catalyst and D2O as deuterium source. This protocol is highly efficient, simply manipulated, and appliable for deuterium-labeling of over 55 (hetero)aryl bromides including bioactive druglike molecules and key intermediates of functional materials. In addition, this method showed distinguishing site-selectivity toward the existing transition-metal-catalyzed HIE process, leading to multideuterated (hetero)aryl bromides in one step.