2-(Pyridin-2-yl)quinoline

Base Information

• Chemical Name: 2-(Pyridin-2-yl)quinoline
• CAS No.: 7491-86-3
• Molecular Formula: C15H10N2O2
• Molecular Weight: 206.247
• European Community (EC) Number: 633-292-9
• Nikkaji Number: J259.005K
• Mol file: 7491-86-3.mol

Synonyms:2-(pyridin-2-yl)quinoline;2-(2-Pyridyl)quinoline;2-(2-Pyridinyl)quinoline;2-pyridin-2-ylquinoline;pyridylquinoline;TimTec1_000732;Oprea1_265434;2-(2-Pyridinyl)quinoline #;SCHEMBL500395;Quinoline, 2-(2-pyridinyl)-;HMS1536B06;AKOS005079382;SB70697;11T-0821;BRD-K31312156-001-01-7

Chemical Property of 2-(Pyridin-2-yl)quinoline

Chemical Property:

• Vapor Pressure: 1.03E-09mmHg at 25°C
• Boiling Point: 472°Cat760mmHg
• Flash Point: 239.2°C
• PSA: 63.08000
• Density: 1.332g/cm³
• LogP: 2.99500
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 206.084398327
• Heavy Atom Count: 16
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

2-(2-PYRIDINYL)QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=CC=CC=N3

Technology Process of 2-(Pyridin-2-yl)quinoline

There total 2 articles about 2-(Pyridin-2-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-bromoquinoline (2005-43-8) + 2-tri-n-butylstannylpyridine (17997-47-6) → 2-(2-pyridinyl)quinoline (7491-86-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 110 ℃; for 17h; Inert atmosphere;

Reference yield: 57.0%

2-methylsulfinylpyridine (21948-75-4) + methyl 2-quinolyl sulfoxide (21948-80-1) → [2,2]bipyridinyl (366-18-7) + 2-(2-pyridinyl)quinoline (7491-86-3) + 2,2'-biquinoline (119-91-5)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1246/bcsj.62.3848

Reference yield: 92.0%

2-(2-pyridinyl)quinoline (7491-86-3) + cis-[Pt(DMSO)2(Me)2] + tricyclohexylphosphine (2622-14-2) → C33H45N2PPt (1613512-45-0)

Guidance literature:

2-(2-pyridinyl)quinoline; cis-[Pt(DMSO)2(Me)2]; In acetone; for 5h; Inert atmosphere; Reflux;

tricyclohexylphosphine; In acetone; for 1h; Inert atmosphere;

DOI:10.1002/chem.201304257

upstream raw materials:

2-methylsulfinylpyridine

methyl 2-quinolyl sulfoxide

2-bromoquinoline

2-tri-n-butylstannylpyridine

Downstream raw materials:

acetonitrile

[Pt(2-(2′-pyridyl)quinoline(-H))(Me)(PPh₃)]

[Pt(2-(2′-pyridyl)quinoline(-H))(Cl)(PPh₃)]

C₃₃H₄₅N₂PPt