10.1080/00958972.2010.534140
The research focuses on the synthesis, characterization, and evaluation of the antitumor and cytotoxic activities of a series of mononuclear Ru(II) complexes, specifically [Ru(T)2(S)]2t, where T represents 2,2'-bipyridine or 1,10-phenanthroline, and S denotes various thiosemicarbazone derivatives such as CH3-bitsz, Cl-bitsz, Br-bitsz, tmtsz, and dmtsz. The reactants used in the synthesis include hydrated ruthenium trichloride, 2,2'-bipyridine, 1,10-phenanthroline, and the thiosemicarbazone ligands. The complexes were characterized using UV-Vis, IR, 1H-NMR, FAB-mass spectroscopy, and elemental analysis. The antitumor activity was assessed in vivo against a transplantable murine tumor cell line (Ehrlich’s ascitic carcinoma), and the cytotoxic activity was evaluated in vitro against human cancer cell lines (Molt 4/C8 and CEM) and a murine tumor cell line (L1210). The study aimed to develop potential cytotoxins and explore the antitumor properties of these Ru(II) complexes as alternatives to platinum-based drugs, which are known for their high toxicity.
10.1021/ic000328t
The study focuses on the preparation and characterization of oxorhenium(V) complexes with 2,2'-biimidazole, exploring the strong affinity of coordinated biimidazole for chloride ions via N-H...Cl- hydrogen bonding. The researchers synthesized a series of mononuclear and oxo-bridged dinuclear complexes containing biimidazole (biimH2) and N,N'-dimethylbiimidazole (biimMe2), aiming to understand their stability, spectroscopic properties, and potential applications in areas such as nuclear medicine and radiotherapy. Key chemicals used in the study include N,N'-dimethylbiimidazole, bipyridine, ReOCl3(OPPh3)(Me2S), and ReOCl4, which served as reactants to form the desired rhenium complexes. The study also utilized various solvents and reagents for the synthesis and characterization processes, including IR and NMR spectroscopies and X-ray diffraction for structural determination. The research revealed interesting ligating features of the biimidazole framework, its role in forming chelate rings, and its influence on the stability and properties of the resulting complexes.
10.1039/b206101e
The study focuses on the synthesis and crystal structures of complexes involving 2-mercaptonicotinic acid (HnicSH) with palladium(II), platinum(II), rhenium(III), and molybdenum(VI) and (V). The chemicals used include 2-mercaptonicotinic acid, Pd(II), Pt(II), Re(III), Mo(VI), and Mo(V) salts, as well as ligands like PPh3 (triphenylphosphine) and bipy (2,2'-bipyridine). These chemicals serve to form new complexes, which are characterized by vibrational spectroscopy and NMR. The study aims to understand the coordination modes of the ambidentate ligand HnicSH, which can involve either the sulfur or nitrogen atoms in coordination with the metal centers. The complexes were found to exhibit different coordination modes, such as monodentate (S) and chelating (N,S), and were further investigated for their potential in oxygen atom transfer reactions, with the molybdenum complex showing catalytic activity towards the oxidation of benzoin and PPh3 with dmso.
10.1002/(SICI)1099-0690(199907)1999:7<1745::AID-EJOC1745>3.0.CO;2-B
The research focuses on the development of new water-soluble diamine complexes as catalysts for the hydrogenation of ketones under hydrogen pressure. The purpose of this study was to synthesize reusable catalytic systems that could be easily separated from reaction products, addressing the issue of catalyst recovery and recycling in homogeneously catalyzed chemical processes involving expensive transition metal complexes. The researchers successfully synthesized water-soluble rhodium and iridium complexes functionalized with PO3Na2 groups, which showed remarkable catalytic activities in the reduction of various ketones in basic aqueous media. The key chemicals used in the process included 2,2'-bipyridines, C2-symmetric diamines, sodium phosphonate, and the precursors 1 and 2, which were further reacted with functionalized isocyanates to form the catalytic species. The study concluded that these water-soluble complexes, particularly those based on ligand 2, exhibited high catalytic activity and could be recycled with minimal loss of activity, making them promising candidates for sustainable and efficient catalytic processes.
10.1039/DT9910001755
The study investigates the synthesis, structure, and reactivity of the complex trans,mer-[VCl3(OPMe2Ph)(PMe2Ph)2]. The researchers prepared this complex by adding PMe2Ph to a toluene solution of VOCl3, resulting in the rapid precipitation of a salmon-pink compound. Its octahedral structure was confirmed by X-ray crystallography, with specific bond lengths and angles measured. The complex can react with various ligands such as 2,2'-bipyridine (bipy), tetramethylethylenediamine (tmen), or Et2PCH2CH2PEt2 (depe), yielding [VCl3(OPMe2Ph)(L-L)] complexes. The X-ray crystal structure of mer-[VCl3(OPMe2Ph)(depe)] was also determined. Other reactions explored include protonation with HCl to form [PHMe2Ph][VCl3(OPMe2Ph)], and reduction with MgEtCl or reaction with SiMe3(S,CNEt2) leading to loss of the phosphine oxide ligand. Solution studies using conductivity measurements and EPR spectroscopy revealed that in tetrahydrofuran (THF), the chloro-groups and phosphine ligands are rapidly displaced by the solvent, indicating significant changes in the complex's structure in solution compared to its solid-state form.
10.1016/j.jorganchem.2004.04.030
The study explores the use of a modified conventional microwave oven for the synthesis of over 20 group 6 organometallic compounds, primarily focusing on molybdenum (Mo), tungsten (W), and chromium (Cr) carbonyls. The chemicals involved include hexacarbonyls such as Mo(CO)6, W(CO)6, and Cr(CO)6, which act as starting materials. These compounds react with various ligands, including mono-, bi-, and tridentate ligands like piperidine, 2,2'-bipyridine, 1,10-phenanthroline, pyridine, and phosphines (PPh3, dppm, dppe), to form tetracarbonyl and other complexes. The microwave-assisted reactions generally proceed without the need for an inert atmosphere, resulting in high yields and significantly reduced reaction times compared to conventional methods. For example, cis-[Mo(CO)4(dppe)] is prepared in >95% yield in just 20 minutes. The study also highlights the successful synthesis of dimeric molybdenum(I) cyclopentadienyl complexes, [CpMo(CO)3]2, in 94% yield, and dimolybdenum tetraacetate in 48% yield under an inert atmosphere. The microwave approach allows for the rapid formation of unsaturated, air-sensitive molybdenum-molybdenum triply bonded complexes, enabling complex organometallic reactions to be carried out more efficiently and safely, making them more accessible for both research and teaching purposes.
10.1021/ol503748t
The study presents a novel and practical method for the ?-arylation of tertiary allylic amines using palladium catalysis. The researchers developed a mild and efficient process to achieve high regio- and stereoselectivity in the ?-arylation of these challenging substrates. Key chemicals involved include phenyl diazonium tetrafluoroborate (6a) as the arylating agent, Pd(dba)2 as the palladium catalyst, and 2,2'-bipyridine (L4) as the ligand. The optimized reaction conditions in DMF solvent yielded the desired ?-arylated products with excellent yields and selectivity. The study also highlights the synthesis of several biologically active compounds, such as naftifine, cinnarizine, and flunarizine, using this method. Additionally, the ?-arylated products were evaluated for their inhibitory effects on adenylyl cyclase type I (AC1), identifying potent inhibitors that could have therapeutic potential for treating neuropathic and inflammatory pain. The findings demonstrate a significant advancement in the synthesis of ?-arylated N,N-dialkylallylamines and their potential applications in drug discovery.
10.1021/ja0173019
The study focuses on the mild iridium-catalyzed borylation of arenes, which is a method for the direct functionalization of inert hydrocarbons into organoboron compounds, valuable for organic synthesis. The researchers used iridium(I) precursors combined with 2,2′-bipyridine (bpy) ligands to catalyze the borylation of arenes by bis(pinacolato)diboron (B2pin2), leading to the formation of pinacol arylboronate esters under mild conditions, including room temperature. Key chemicals involved in the study include iridium complexes, bpy ligands, B2pin2, and various arenes. The purpose of these chemicals was to facilitate a reaction that could convert abundant, inert hydrocarbons into more reactive and useful functionalized compounds, specifically arylboronates, which are important intermediates in organic synthesis. The study also aimed to isolate and characterize potential intermediates in the borylation process, which were found to be Ir(III) tris-boryl complexes.
10.1021/om010015l
The study investigates selective ion pairing in the compounds [Ir(bipy)H2(PRPh2)2]A, where A represents various anions such as PF6, BF4, CF3SO3, and BPh4, and R represents different alkyl groups (Me or Ph). The research utilized NMR spectroscopy to reveal that the anion binding site is unexpectedly located on the side of the bipyridyl ligand remote from the metal, rather than near the metal and the MH2 group. The study aimed to understand the structure and mechanism of ion pairing in these organometallic compounds, which is known to influence reaction rates but is often overlooked. The chemicals used served as cations and anions in the complexes under investigation, and their interactions were central to the study's exploration of ion pairing behavior and its implications on the structure and reactivity of the compounds. Theoretical calculations using the ONIOM (QM/MM) method were also employed to model the cation structure and to understand the charge distribution, which was found to predominantly locate on the bipyridyl ring carbons involved in the inter-ring C-C bond, consistent with the experimental NMR findings.
10.1021/ja9099399
The study focuses on the synthesis and characterization of photochromic ruthenium sulfoxide complexes of the form [Ru(bpy)2(OSOR)]+, where bpy is 2,2′-bipyridine and OSOR represents different sulfoxide ligands. These complexes exhibit phototriggered isomerization from an S-bonded to an O-bonded state, which is associated with a change in color. The chemicals used include 2-(benzylsul?nyl)benzoate (OSOBn), 2-(napthalen-2-yl-methylsul?nyl)benzoate (OSONap), and 2-(penta?uorophenylmethanesul?nyl)benzoate (OSOBnF5) as the sulfoxide ligands, along with [Ru(bpy)3]Cl26H2O, RuCl3·xH2O, and AgPF6 as starting materials and reagents. The purpose of these chemicals is to create complexes that can switch between two distinct states upon exposure to light, which has potential applications in molecular switches, logic gates, and other photoresponsive materials. The study aims to understand the relationship between the distortion energy of the 3MLCT state and isomerization reactivity, as well as the effect of electronic and steric factors on excited state isomerization by varying the substituent on the sulfur in the complexes.
10.1023/A:1016024531639
The research aimed to investigate the reactivity of nickel(0) complexes coordinated with 2,2'-bipyridine (bpy) in the electrochemical reduction of organic halides. The study focused on understanding the mechanism of the catalytic process and identifying the intermediates formed during the reduction. The researchers used nickel complexes with varying numbers of bpy ligands and different organic halides, including alkyl and aryl halides such as propyl iodide, amyl iodide, phenyl bromide, and mesityl bromide. The experiments involved electrochemical techniques like cyclic voltammetry and preparative electrolysis. The study concluded that nickel(0) complexes with fewer bpy ligands were more reactive in the oxidative addition to organic halides, leading to the formation of σ-organonickel intermediates.
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