1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Base Information

• Chemical Name: 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester
• CAS No.: 518990-56-2
• Molecular Formula: C12H17N3O4
• Molecular Weight: 267.285
• Hs Code.: 2933998090
• Mol file: 518990-56-2.mol

Synonyms:1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester;5-Boc-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-3-carboxylic acid;5-(tert-butoxycarbonyl) 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid

Chemical Property of 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Chemical Property:

• PSA: 95.52000
• LogP: 1.33900

Purity/Quality:

99%, ^*data from raw suppliers

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

There total 3 articles about 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.45%

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate (518990-23-3) → 5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid (518990-56-2)

Guidance literature:

With methanol; water; sodium hydroxide; at 40 ℃; for 12h;

Reference yield:

tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate (518990-24-4) → 5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid (518990-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; acetic acid / 1 h / 80 °C / Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 20 h / 40 - 50 °C / Inert atmosphere

With water; hydrazine hydrate; acetic acid; sodium hydroxide; In tetrahydrofuran;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxylic acid (518990-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 2.5 h / 15 °C

2.1: hydrazine hydrate; acetic acid / 1 h / 80 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 20 h / 40 - 50 °C / Inert atmosphere

With water; hydrazine hydrate; acetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate

tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

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