3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 518990-24-4
• Molecular Formula: C14H21NO6
• Molecular Weight: 299.324
• Hs Code.: 2933399090
• Mol file: 518990-24-4.mol

Synonyms:3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester;3-Piperidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-a,4-dioxo-, ethyl ester;Ethyl 2-Oxo-2-(1-Boc-4-oxo-3-piperidyl)acetate;(1-Boc-4-oxo-piperidin-3-yl)-oxo-acetic acid ethyl ester

Chemical Property of 3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 420.1±45.0 °C(Predicted)
• PKA: 7.25±0.20(Predicted)
• PSA: 89.98000
• Density: 1.202
• LogP: 0.88260
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(1-Boc-4-oxo-piperidin-3-yl)-oxo-aceticacidethylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + oxalic acid diethyl ester (95-92-1) → tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate (518990-24-4)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; acetone; at -78 ℃; for 0.5h;

oxalic acid diethyl ester; In tetrahydrofuran; ethyl acetate; acetone; at -78 - 20 ℃;

Reference yield:

tert-butyl 5-(2-ethoxy-2-oxoacetyl)-4-(pyrrolidin-1-yl)-3,6-dihydropyridine-1(2H)-carboxylate → tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate (518990-24-4)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 2h; Sealed tube;

DOI:10.1016/j.bmcl.2019.07.003

Reference yield:

N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine (207691-65-4) → tert-butyl 3-(2-ethoxy-2-oxo-acetyl)-4-oxo-piperidine-1-carboxylate (518990-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / dichloromethane; water / 2 h / 20 °C / Sealed tube

With hydrogenchloride; triethylamine; In dichloromethane; water;

DOI:10.1016/j.bmcl.2019.07.003

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

oxalic acid diethyl ester

N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine

Downstream raw materials:

5‐tert‐butyl 3‐ethyl 1,4,6,7‐tetrahydro‐5H‐pyrazolo[4,3‐c]pyridine‐3,5‐dicarboxylate

C₉H₁₃N₃O₂*ClH

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 518990-24-4 3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send