2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL

Base Information

• Chemical Name: 2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL
• CAS No.: 944064-51-1
• Molecular Formula: C16H20O2Si
• Molecular Weight: 272.419
• Hs Code.: 2905190098
• Mol file: 944064-51-1.mol

Synonyms:2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL;{2-[(4-Methoxyphenyl)dimethylsilyl]phenyl}methanol

Chemical Property of 2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL

Chemical Property:

• PSA: 29.46000
• LogP: 2.01010

Purity/Quality:

97% ^*data from raw suppliers

{2-[(4-Methoxy-phenyl)-dimethyl-silanyl]-phenyl}-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL

There total 5 articles about 2-[(4-METHOXYPHENYL)DIMETHYLSILYL]BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + 1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole (321903-29-1) → [2-(hydroxymethyl)phenyl]dimethyl(4-methoxyphenyl)silane (944064-51-1)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja071969r

Reference yield: 70.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole (321903-29-1) → [2-(hydroxymethyl)phenyl]dimethyl(4-methoxyphenyl)silane (944064-51-1)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.tetlet.2011.10.126

Reference yield:

o-bromobenzyl alcohol (18982-54-2) → [2-(hydroxymethyl)phenyl]dimethyl(4-methoxyphenyl)silane (944064-51-1)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water / 20 °C

2: n-butyllithium

3: methanol / Acidic conditions

4: tetrahydrofuran

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tetlet.2011.10.126

upstream raw materials:

4-methoxyphenyl magnesium bromide

1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole

dimethyl(2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)silane

1-bromo-4-methoxy-benzene

Downstream raw materials:

1-(4-chlorobenzyl)-4-methoxybenzene

3-(4-methoxyphenyl)cyclohexanone

1,1-dimethyl-1,3-dihydrobenzo[c][1,2]oxasilole

N,N-dibenzyl-4-anisidine

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