Fluorobexarotene

Base Information

Chemical Name:Fluorobexarotene
CAS No.:1190848-23-7
Molecular Formula:C24H27FO2
Molecular Weight:366.476
Hs Code.:
Mol file:1190848-23-7.mol

Synonyms:Fluorobexarotene

Suppliers and Price of Fluorobexarotene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fluorobexarotene
10mg
$ 245.00

Tocris
Fluorobexarotene ≥97%(HPLC)
10
$ 267.00

ChemScene
Fluorobexarotene >97.0%
10mg
$ 950.00

ChemScene
Fluorobexarotene >97.0%
5mg
$ 560.00

ApexBio Technology
Fluorobexarotene
10mg
$ 402.00

AK Scientific
Fluorobexarotene
1mg
$ 166.00

AK Scientific
Fluorobexarotene
5mg
$ 364.00

Total 7 raw suppliers

Chemical Property of Fluorobexarotene

Chemical Property:

PSA：37.30000
LogP:6.24280

Purity/Quality:

97% ^*data from raw suppliers

Fluorobexarotene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Fluorobexarotene is a retinoid X receptor (RXR) agonist, which facilitates β-amyloid clearance across blood-brain barrier; RXR activation has the potential to mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of Alzheimer’s disease.

Technology Process of Fluorobexarotene

There total 11 articles about Fluorobexarotene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1190848-49-7
methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

: 1190848-23-7
2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid

Guidance literature:: methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate; With water; potassium hydroxide; In methanol; for 1h; Reflux;

With hydrogenchloride; In methanol; water; at 20 ℃;
DOI:10.1021/jm900496b

Reference yield:

: 110-03-2
2,5-dimethyl-2,5-hexanediol

: 1190848-23-7
2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 20 °C / Reflux

3.1: aluminum (III) chloride / dichloromethane / 0.58 h / 20 °C / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: potassium hydroxide / water; methanol / 2 h / Reflux

With hydrogenchloride; aluminum (III) chloride; n-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 2.1: |Friedel-Crafts Alkylation / 3.1: |Friedel-Crafts Acylation / 4.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2014.02.037

Reference yield:

: 1190848-45-3
methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

: 1190848-23-7
2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium hydroxide / water; methanol / 2 h / Reflux

With n-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; hexane; water; 1.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2014.02.037