methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

Base Information

Chemical Name:methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate
CAS No.:1190848-49-7
Molecular Formula:C₂₅H₂₉FO₂
Molecular Weight:380.502
Hs Code.:

Synonyms:methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

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Chemical Property of methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

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Technology Process of methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

There total 11 articles about methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1190848-45-3
methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1190848-49-7
methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate; In tetrahydrofuran; hexane; at 20 ℃;
DOI:10.1021/jm900496b

Reference yield: 19.0%

: 1190848-45-3
methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate

: 27200-84-6
methyl triphenylphosphonium bromide

: 1190848-49-7
methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

Guidance literature:: methyl triphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.02.037

Reference yield:

: 110-03-2
2,5-dimethyl-2,5-hexanediol

: 1190848-49-7
methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 20 °C / Reflux

3.1: aluminum (III) chloride / dichloromethane / 0.58 h / 20 °C / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C

4.2: 1 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; 2.1: |Friedel-Crafts Alkylation / 3.1: |Friedel-Crafts Acylation / 4.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2014.02.037