2-BROMOBUTANOIC ACID

Base Information

• Chemical Name: 2-BROMOBUTANOIC ACID
• CAS No.: 2385-70-8
• Molecular Formula: C₄H₇BrO₂
• Molecular Weight: 167.002
• Mol file: 2385-70-8.mol

Synonyms:L(-)-2-Brom-buttersaeure;Butanoic acid, 2-bromo-, (±)-;2-BROMOBUTANOIC ACID;(S)-2-bromobutyric acid;(S)-2-Brom-buttersaeure;(S)-2-bromo-butyric acid;

Chemical Property of 2-BROMOBUTANOIC ACID

Chemical Property:

• Melting Point: -2°C
• Refractive Index: 1.5080 (estimate)
• PSA: 37.30000
• Density: 1.5641
• LogP: 1.24450

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMOBUTANOIC ACID

There total 6 articles about 2-BROMOBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

L-2-aminobutyric acid (1492-24-6) → (S)-2-bromobutanoic acid (80-58-0,2385-70-8,2681-94-9,32659-49-7)

Guidance literature:

With sulfuric acid; potassium bromide; sodium nitrite; at -5 ℃; for 1.5h;

DOI:10.1021/jo00360a015

Reference yield: 47.0%

methyl bromo-crotonate (17642-18-1,36297-23-1,22966-48-9) → (S)-2-bromobutanoic acid (80-58-0,2385-70-8,2681-94-9,32659-49-7)

Guidance literature:

With D-glucose; In ethanol; water; at 30 ℃; for 72h; optical yield given as %ee; enantioselective reaction; Microbiological reaction;

DOI:10.1021/op200086t

Reference yield:

(αS,3R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-bromobutyrate → (S)-2-bromobutanoic acid (80-58-0,2385-70-8,2681-94-9,32659-49-7) + (R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one (169221-13-0)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 7h;

DOI:10.1016/j.tetasy.2005.10.014

upstream raw materials:

L-2-aminobutyric acid

2-Bromobutyric acid

hydrogen bromide

methyl bromo-crotonate

Downstream raw materials:

(R)-2-pyrrolidone-N-butyric acid

L-2-bromobutyric acid (+)-α-methylbenzyl amide

Refernces

• 1、 Liu, Weiguo,Liu, Kun,Wood, Harold B.,McCann, Margaret E.,Doebber, Thomas W.,Chang, Ching H.,Akiyama, Taro E.,Einstein, Monica,Berger, Joel P.,Meinke, Peter T.. "Discovery of a peroxisome proliferator activated receptor γ (PPARγ) modulator with balanced PPARα activity for the treatment of type 2 diabetes and dyslipidemia". supporting information; experimental part. p. 4443 - 4453. Retrieved 2010/03/02.
• 2、 Ferorelli,Loiodice,Tortorella,Amoroso,Bettoni,Conte- Camerino,De Luca. "Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity". . p. 367 - 374. Retrieved 2007/10/03.