Levetiracetam acid

Base Information

• Chemical Name: Levetiracetam acid
• CAS No.: 103833-72-3
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.196
• Mol file: 103833-72-3.mol

Synonyms:(R)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid;

Chemical Property of Levetiracetam acid

Chemical Property:

• Melting Point: 124-126 °C
• Boiling Point: 370.975 °C at 760 mmHg
• PKA: 3.76±0.10(Predicted)
• Flash Point: 178.16 °C
• PSA: 57.61000
• Density: 1.227 g/cm³
• LogP: 0.40990
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Slightly, Sonicated), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(R)-EtiracetamAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Levetiracetam Acid can be used as reactant/reagent in synthesis, Aβ42/tau aggregation, acetylcholinesterase/butyrylcholinesterase inhibitory activities, acute toxicity, and docking studies of levetiracetam-huprine/tacrine hybrids as anti-Alzheimer''s agents.

Technology Process of Levetiracetam acid

There total 6 articles about Levetiracetam acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ (R)-2-pyrrolidone-N-butyric acid (103833-72-3)

Guidance literature:

Reference yield: 87.1%

1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one (909566-58-1) → (R)-2-pyrrolidone-N-butyric acid (103833-72-3) + (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid (102849-49-0)

Guidance literature:

With 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; water; In aq. buffer; for 11h; pH=9; Overall yield = 92 percentSpectr.; Electrolysis;

DOI:10.1021/acs.oprd.1c00036

Reference yield: 62.0%

2-pyrrolidinon (616-45-5) + (S)-2-bromobutanoic acid (80-58-0,2385-70-8,2681-94-9,32659-49-7) → (R)-2-pyrrolidone-N-butyric acid (103833-72-3)

Guidance literature:

2-pyrrolidinon; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.75h;

(S)-2-bromobutanoic acid; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.tetasy.2005.10.014

upstream raw materials:

(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-(2-oxopyrrolidin-1-yl)butyrate

2-pyrrolidinon

(S)-2-bromobutanoic acid

α-ethyl-2-oxo-1-pyrrolidineacetic acid,

Downstream raw materials:

levetiracetam

Refernces

• 1、 -. "IMPROVED PROCESS FOR THE PREPARATION OF (S)-ALPHA-ETYL-2-OXO-1-PYRROLIDINEACETAMIDE AND (R)-ALPHA-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE". Page/Page column 14. . Retrieved 2008/06/13.
• 2、 -. "Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide". . . Retrieved 2008/06/13.