4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE
• CAS No.: 325808-20-6
• Molecular Formula: C₁₂H₁₇NO*ClH
• Molecular Weight: 227.734
• Hs Code.: 2933399090
• Mol file: 325808-20-6.mol

Synonyms:4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE;4-(3-Methoxyphenyl)-piperidine HCl;Piperidine, 4-(3-methoxyphenyl)-

Chemical Property of 4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 21.26000
• LogP: 3.29300

Purity/Quality:

97% ^*data from raw suppliers

4-(3-Methoxyphenyl)piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE

There total 5 articles about 4-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride → 4-(3-methoxyphenyl)piperidine hydrogen chloride salt (325808-20-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 16h; under 760 Torr;

DOI:10.1248/cpb.48.1978

Reference yield:

1-benzyl-4-(3-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine (99329-65-4) → 4-(3-methoxyphenyl)piperidine hydrogen chloride salt (325808-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; ethyl acetate

2: palladium 10% on activated carbon; hydrogen / ethanol / 48 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In diethyl ether; ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-ol (99329-68-7) → 4-(3-methoxyphenyl)piperidine hydrogen chloride salt (325808-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonic acid / toluene / 4 h / Reflux

2: hydrogenchloride / diethyl ether; ethyl acetate

3: palladium 10% on activated carbon; hydrogen / ethanol / 48 h

With hydrogenchloride; methanesulfonic acid; palladium 10% on activated carbon; hydrogen; In diethyl ether; ethanol; ethyl acetate; toluene;

DOI:10.1016/j.bmcl.2012.01.122

upstream raw materials:

1-phenylmethyl-4-piperidone

1-benzyl-4-(3-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridine

1-Benzyl-4-(3-methoxy-phenyl)-piperidin-4-ol

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