MHY 908

Base Information

Chemical Name:MHY 908
CAS No.:1393371-39-5
Molecular Formula:C17H14ClNO3S
Molecular Weight:347.82
Hs Code.:
Mol file:1393371-39-5.mol

Synonyms:MHY 908

Suppliers and Price of MHY 908

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MHY908
25mg
$ 905.00

TRC
MHY908
10mg
$ 450.00

Cayman Chemical
MHY908 ≥98%
1mg
$ 65.00

Cayman Chemical
MHY908 ≥98%
500μg
$ 38.00

Cayman Chemical
MHY908 ≥98%
10mg
$ 418.00

Cayman Chemical
MHY908 ≥98%
5mg
$ 247.00

Axon Medchem
MHY908 99%
5 mg
$ 104.50

AK Scientific
2-(4-(5-Chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoicacid
5mg
$ 433.00

Total 4 raw suppliers

Chemical Property of MHY 908

Chemical Property:

PSA：87.66000
LogP:4.85870

Purity/Quality:

99% ^*data from raw suppliers

MHY908 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 μM. In vivo, MHY908 (3 mg/kg per day) reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis by reducing hepatic triglyceride levels and lipid droplet accumulation in db/db mice and 20-month-old rats. It reduces peroxynitrite and COX-2 levels, reactive oxygen species (ROS) production, and Akt phosphorylation in isolated kidney from 20-month-old rats when administered at a dose of 3 mg/kg. MHY908 inhibits mushroom tyrosinase (IC50 = 8.19 μM). It also inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells when used at a concentration of 10 μM.
Uses MHY908 is a dual agonist of PPARα and PPARγ.

Technology Process of MHY 908

There total 3 articles about MHY 908 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

: 85212-83-5
2-(4-formylphenoxy)-2-methylpropanoic acid

: 1004-00-8
4-chloro-2-aminobenzenethiol

: 1393371-39-5
2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: With sodium acetate; acetic acid; for 1h; Reflux;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1393371-39-5
2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 12.5 h / Reflux

2: sodium hydroxide; water / 1,4-dioxane / 4 h / 20 °C

3: sodium acetate; acetic acid / 1 h / Reflux

With water; sodium ethanolate; sodium acetate; acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol;

Reference yield:

: 51336-35-7
α-(4-formylphenoxy)isobutyric acid ethyl ester

: 1393371-39-5
2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / 1,4-dioxane / 4 h / 20 °C

2: sodium acetate; acetic acid / 1 h / Reflux

With water; sodium acetate; acetic acid; sodium hydroxide; In 1,4-dioxane;