Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate

Base Information

Chemical Name:Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate
CAS No.:205251-35-0
Molecular Formula:C21H33N3O4
Molecular Weight:391.511
Hs Code.:
DSSTox Substance ID:DTXSID10694570
Mol file:205251-35-0.mol

Synonyms:DTXSID10694570;Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate

Suppliers and Price of Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R,R)-N-BENZYL-3,4-TRANS-(N-BOC)- DIAMINOPYRROLIDINE 95.00%
5MG
$ 501.82

Total 6 raw suppliers

Chemical Property of Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate

Chemical Property:

PSA：79.90000
LogP:4.00850
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:391.24710654
Heavy Atom Count:28
Complexity:495

Purity/Quality:

97% ^*data from raw suppliers

(R,R)-N-BENZYL-3,4-TRANS-(N-BOC)- DIAMINOPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CN(CC1NC(=O)OC(C)(C)C)CC2=CC=CC=C2

Technology Process of Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate

There total 7 articles about Di-tert-butyl (1-benzylpyrrolidine-3,4-diyl)biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 140134-21-0,246149-02-0
(3S,4S)-1-benzyl-pyrrolidine-3,4-diamine

: 205251-35-0
N-benzyl-3,4-di(Boc-amino)pyrrolidine

Guidance literature:: In dichloromethane; Ambient temperature;
DOI:10.1016/S0960-894X(98)00063-8

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 140134-20-9
(3R,4R)-3,4-diazido-1-benzylpyrrolidine

: 205251-35-0
N-benzyl-3,4-di(Boc-amino)pyrrolidine

Guidance literature:: With hydrogen; Lindlar's catalyst; In methanol; at 20 ℃; for 2h; under 760 Torr;

Reference yield:

: 90365-74-5,330152-66-4
(3S,4S)-(+)-1-benzyl-3,4-pyrrolidinediol

: 205251-35-0
N-benzyl-3,4-di(Boc-amino)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / HN₃; DEAD; PPh₃

2: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

3: 1.5 g / NaOH / H₂O; dioxane / 2 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; 1: Substitution / 2: Reduction / 3: Acylation;
DOI:10.1021/jo991628z