Multi-step reaction with 7 steps
1: 89 percent / NaH / dimethylformamide / Ambient temperature
2: 96 percent / NaBH4 / tetrahydrofuran; ethanol / 0.75 h / Ambient temperature
3: 70 percent / LiBr, 2,6-lutidine, methanesulfonic anhydride / tetrahydrofuran / 30 h / Ambient temperature
4: 42 percent / n-BuLi, isopropylcyclohexylamine, HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C
5: 79 percent / LiAlH4 / diethyl ether / 0.33 h / Ambient temperature
6: 97 percent / 3 N HCl / methanol / 1 h / Heating
7: 88 percent / Ph3P, DEAD / tetrahydrofuran / 1 h / Ambient temperature
With
2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; N-cyclohexylisopropylamine; sodium hydride; triphenylphosphine; lithium bromide; diethylazodicarboxylate; Methanesulfonic anhydride;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.3987/com-98-8149