3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol

Base Information

• Chemical Name: 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol
• CAS No.: 213970-42-4
• Molecular Formula: C₁₈H₂₂O₅
• Molecular Weight: 318.37
• Mol file: 213970-42-4.mol

Synonyms:3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol

Chemical Property of 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol

There total 6 articles about 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2,4-dimethoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol (213970-38-8) → 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol (213970-42-4)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.3987/com-98-8149

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol (213970-42-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 89 percent / NaH / dimethylformamide / Ambient temperature

2: 96 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.75 h / Ambient temperature

3: 70 percent / LiBr, 2,6-lutidine, methanesulfonic anhydride / tetrahydrofuran / 30 h / Ambient temperature

4: 42 percent / n-BuLi, isopropylcyclohexylamine, HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

5: 79 percent / LiAlH₄ / diethyl ether / 0.33 h / Ambient temperature

6: 97 percent / 3 N HCl / methanol / 1 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; N-cyclohexylisopropylamine; sodium hydride; lithium bromide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;

DOI:10.3987/com-98-8149

Reference yield:

4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1) → 3-(2-hydroxy-4-methoxyphenyl)-2-(2,4-dimethoxyphenyl)-1-propanol (213970-42-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.75 h / Ambient temperature

2: 70 percent / LiBr, 2,6-lutidine, methanesulfonic anhydride / tetrahydrofuran / 30 h / Ambient temperature

3: 42 percent / n-BuLi, isopropylcyclohexylamine, HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

4: 79 percent / LiAlH₄ / diethyl ether / 0.33 h / Ambient temperature

5: 97 percent / 3 N HCl / methanol / 1 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; N-cyclohexylisopropylamine; lithium bromide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane;

DOI:10.3987/com-98-8149

upstream raw materials:

2-(2,4-dimethoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol

2-Hydroxy-4-methoxybenzaldehyde

4-methoxy-2-methoxymethoxy benzaldehyde

2-(methoxymethoxy)-4-methoxybenzyl alcohol

Downstream raw materials:

2',4',7-trimethoxyisoflavan