2-bromo-3-fluoro-4,6-dimethylaniline

Base Information

• Chemical Name: 2-bromo-3-fluoro-4,6-dimethylaniline
• CAS No.: 444-02-0
• Molecular Formula: C₈H₉BrFN
• Molecular Weight: 218.069

Synonyms:

Chemical Property of 2-bromo-3-fluoro-4,6-dimethylaniline

Chemical Property:

• Vapor Pressure: 0.0107mmHg at 25°C
• Boiling Point: 262.7°Cat760mmHg
• Flash Point: 112.7°C
• Density: 1.507g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-3-fluoro-4,6-dimethylaniline

There total 2 articles about 2-bromo-3-fluoro-4,6-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-2,4-dimethylaniline (400-02-2) → 2-bromo-3-fluoro-4,6-dimethyl-aniline (444-02-0)

Guidance literature:

With bromine; acetic acid;

DOI:10.1021/ja01346a050

Reference yield:

1-fluoro-2,4-dimethyl-5-nitro-benzene (345-22-2) → 2-bromo-3-fluoro-4,6-dimethyl-aniline (444-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; aqueous hydrochloric acid

2: acetic acid; bromine

With hydrogenchloride; bromine; iron; acetic acid;

DOI:10.1021/ja01346a050

Reference yield:

2-bromo-3-fluoro-4,6-dimethyl-aniline (444-02-0) → 2-bromo-3-fluoro-4,6-dimethyl-5-nitro-aniline (314-38-5)

Guidance literature:

With sulfuric acid; nitric acid;

DOI:10.1021/ja01346a050

upstream raw materials:

5-fluoro-2,4-dimethylaniline

1-fluoro-2,4-dimethyl-5-nitro-benzene

Downstream raw materials:

2-bromo-3-fluoro-4,6-dimethyl-5-nitro-aniline

1-bromo-2-chloro-6-fluoro-3,5-dimethyl-4-nitro-benzene

Refernces

Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties

10.3906/kim-1711-97

The study focuses on the synthesis, solvatochromism, and biological activity of novel azo dyes that incorporate 2-pyridone and benzimidazole moieties. The azo dyes were synthesized through the diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and subsequent coupling with substituted 3-cyano-2-pyridones. The dyes were characterized using UV-Vis, FT-IR, and NMR spectroscopy, as well as elemental analysis. The study explored the solvatochromism of the dyes across various solvents and investigated their tautomeric forms. Biological tests, including MTT assays, revealed that the dyes exhibit good biocompatibility and antiproliferative activity against tumor cell lines MDA-MB-231 and HCT-116, suggesting potential applications in cancer treatment.

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