(4-BroMothiazol-2-yl)MethanaMine

Base Information

• Chemical Name: (4-BroMothiazol-2-yl)MethanaMine
• CAS No.: 697299-86-8
• Molecular Formula: C4H5BrN2S
• Molecular Weight: 193.0649
• Hs Code.: 2934100090
• Mol file: 697299-86-8.mol

Synonyms:(4-BroMothiazol-2-yl)MethanaMine;C-(4-Bromo-thiazol-2-yl)-methylamine;(4-Bromo-thiazol-2-yl)-methylamine;1-(4-Bromo-1,3-thiazol-2-yl)methanamine;(4-bromo-1,3-thiazol-2-yl)methanamine

Chemical Property of (4-BroMothiazol-2-yl)MethanaMine

Chemical Property:

• PSA: 67.15000
• LogP: 2.06460

Purity/Quality:

NLT 98% ^*data from raw suppliers

(4-Bromothiazol-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-BroMothiazol-2-yl)MethanaMine

There total 2 articles about (4-BroMothiazol-2-yl)MethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-Azidomethyl-4-bromo-thiazole (697299-85-7) → 1-(4-bromo-1,3-thiazol-2-yl)methanamine (697299-86-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; for 3h;

Reference yield:

2-[(4-bromo-1,3-thiazol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione (1156520-27-2) → 1-(4-bromo-1,3-thiazol-2-yl)methanamine (697299-86-8)

Guidance literature:

With ethanol; hydrazine hydrate; for 24h; Reflux;

Reference yield: 72.0%

1-(4-bromo-1,3-thiazol-2-yl)methanamine (697299-86-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl ((4-bromothiazol-2-yl)methyl)carbamate (697299-87-9)

Guidance literature:

In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; at 20 ℃; for 4h;

upstream raw materials:

2-Azidomethyl-4-bromo-thiazole

2-[(4-bromo-1,3-thiazol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

tert-butyl ((4-bromothiazol-2-yl)methyl)carbamate

N-[(4-bromo-1,3-thiazol-2-yl)methyl]formamide

Refernces

• 1、 -. "Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors". Page/Page column 10. . Retrieved 2008/06/13.