CNX-1351

Base Information

• Chemical Name: CNX-1351
• CAS No.: 1276105-89-5
• Molecular Formula: C30H35N7O3S
• Molecular Weight: 573.709
• Mol file: 1276105-89-5.mol

Synonyms:CNX-1351;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351;CNX-1351, >=98%

Chemical Property of CNX-1351

Chemical Property:

• PSA: 135.79000
• LogP: 3.97170

Purity/Quality:

99%, ^*data from raw suppliers

CNX-1351 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CNX-1351

There total 6 articles about CNX-1351 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-(1H-indazol-4-yl)-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine + 6-methyl-4-oxohept-5-enoic acid (54608-07-0) → 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione (1276105-89-5)

Guidance literature:

6-methyl-4-oxohept-5-enoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

4-(2-(1H-indazol-4-yl)-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃;

DOI:10.1021/jm3008745

Reference yield:

4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester (885699-79-6) → 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione (1276105-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl acetamide; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogenchloride; methanol / dichloromethane; 1,4-dioxane / 1 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide / 0.5 h / 20 °C

3.2: 20 °C

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; 1.1: |Suzuki Coupling;

DOI:10.1021/jm3008745

Reference yield:

C20H26ClN5O4S → 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione (1276105-89-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 10 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl acetamide; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogenchloride; methanol / dichloromethane; 1,4-dioxane / 1 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide / 0.5 h / 20 °C

4.2: 20 °C

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tris(acetoxy)borohydride; sodium carbonate; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane; 2.1: |Suzuki Coupling;

DOI:10.1021/jm3008745

upstream raw materials:

6-methyl-4-oxohept-5-enoic acid

4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

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