2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE

Base Information

• Chemical Name: 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
• CAS No.: 885618-31-5
• Molecular Formula: C11H10 Cl N3 O2 S
• Molecular Weight: 283.738
• Hs Code.: 2934999090
• Mol file: 885618-31-5.mol

Synonyms:2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine-6-carboxaldehyde

Chemical Property of 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE

Chemical Property:

• PSA: 83.56000
• Density: 1.522g/cm3
• LogP: 2.05880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE

There total 10 articles about 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-chloro-4-morpholinothieno[3,2-d]pyrimidine (16234-15-4) → 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde (885618-31-5)

Guidance literature:

2-chloro-4-morpholinothieno[3,2-d]pyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -60 ℃; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h;

Reference yield: 98.0%

2-chloro-4-morpholinothieno[3,2-d]pyrimidine (16234-15-4) → 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde (885618-31-5)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; water; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

Reference yield: 80.1%

→ 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde (885618-31-5)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at -10 ℃; for 0.5h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; at -10 ℃; for 2.5h; Inert atmosphere;

In tetrahydrofuran; for 2.5h; Inert atmosphere;

upstream raw materials:

N,N-dimethyl-formamide

2-chloro-4-morpholinothieno[3,2-d]pyrimidine

2,4-dichlorothieno[3,2-d]pyrimidine

1H-thieno[3,2-d]pyrimidine-2,4-dione

Downstream raw materials:

4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine

2-chloro-6-(4-methylpiperazin-1-yl-methyl)4-morpholin-4-yl-thieno[3,2-d]pyrimidine

C₁₇H₂₄ClN₅O₂S

1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine

Refernces

• 1、 -. "PARP-1/PI3K double-target inhibitor or pharmaceutically acceptable salt thereof, preparation method and application thereof". Paragraph 0157; 0168-0170; 0191; 0201-0203. . Retrieved 2021/07/01.
• 2、 Hu, Rong,Liu, Zhi-Hao,Wang, Ning-Yu,Wang, Wan-Li,Xu, Ying,Yu, Luo-Ting,Zhu, Yong-Xia,Zuo, Wei-Qiong. "Design, synthesis and structure-activity relationship study of piperazinone-containing thieno[3,2-d]pyrimidine derivatives as new PI3Kδ inhibitors". supporting information. . Retrieved 2020/08/14.