(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Base Information

Chemical Name:(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
CAS No.:114414-57-2
Molecular Formula:C32H34N2O12
Molecular Weight:638.61856
Hs Code.:
Mol file:114414-57-2.mol

(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Synonyms:(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;Cyanomorpholinylanthracycline

Suppliers and Price of (8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Chemical Property:

Purity/Quality:

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Technology Process of (8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

There total 2 articles about (8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 7456-83-9
2,2'-oxybis(acetaldehyde)

: 25316-40-9
doxorubicin hydrochloride

: 89164-77-2,89164-78-3,89673-78-9
3'-deamino-3'-(3-cyano-4-morpholinyl)-13-dihydrodoxorubicin

: 80875-73-6
3'-deamino-3'-(4-morpholinyl)-13-dihydrodoxorubicin

: 80790-68-7
3'-deamino-3'-(4-morpholinyl)doxorubicin

: 88254-07-3,114414-57-2,89196-07-6
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin

Guidance literature:: With sodium cyanoborohydride; In water; acetonitrile;
DOI:10.1021/jm00371a014

Reference yield: 30.0%

: 7456-83-9
2,2'-oxybis(acetaldehyde)

: 25316-40-9
doxorubicin hydrochloride

: 75-05-8,26809-02-9
acetonitrile

: 89164-77-2,89164-78-3,89673-78-9
3'-deamino-3'-(3-cyano-4-morpholinyl)-13-dihydrodoxorubicin

: 80875-73-6
3'-deamino-3'-(4-morpholinyl)-13-dihydrodoxorubicin

: 80790-68-7
3'-deamino-3'-(4-morpholinyl)doxorubicin

: 88254-07-3,114414-57-2,89196-07-6
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin

Guidance literature:: With citrate buffer; sodium cyanoborohydride; Yield given. Multistep reaction; 1.) H₂O;
DOI:10.1021/jm00371a014

Reference yield:

: 88254-07-3,114414-57-2,89196-07-6
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin

: 89164-85-2,89196-11-2,89617-39-0
14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(3-cyano-4-morpholinyl)-5-iminodoxorubicin

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / pyridine / 48 h

2: NH₃ / methanol; CH₂Cl₂ / 27 h / 30 °C

With pyridine; ammonia; In methanol; dichloromethane;
DOI:10.1021/jm00371a014