5-(4-ethylpiperazin-1-yl)pyridin-2-amine

Base Information

• Chemical Name: 5-(4-ethylpiperazin-1-yl)pyridin-2-amine
• CAS No.: 1018505-59-3
• Molecular Formula: C11H18N4
• Molecular Weight: 206.29
• Mol file: 1018505-59-3.mol

Synonyms:5-(4-ethylpiperazin-1-yl)pyridin-2-amine;5-(4-ETHYL-1-PIPERAZINYL)-2-PYRIDINAMINE;OTAVA-BB 1119869;5-(4-Ethyl-piperazin-1-yl)-pyridin-2-ylamine

Chemical Property of 5-(4-ethylpiperazin-1-yl)pyridin-2-amine

Chemical Property:

• PSA: 45.39000
• LogP: 1.38980
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Ethylpiperazin-1-yl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-ethylpiperazin-1-yl)pyridin-2-amine

There total 5 articles about 5-(4-ethylpiperazin-1-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-ethyl-4-(6-nitropyridin-3-yl)piperazine (1333509-07-1) → 5-(4-ethylpiperazin-l-yl)-pyridin-2-ylamine (1018505-59-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b01670

Reference yield: 82.0%

→ 5-(4-ethylpiperazin-l-yl)-pyridin-2-ylamine (1018505-59-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

4-ethylpiperazine (5308-25-8) → 5-(4-ethylpiperazin-l-yl)-pyridin-2-ylamine (1018505-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 3 h / 120 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 1 h / 20 °C / 2068.65 Torr / Inert atmosphere

With hydrogen; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; ethyl acetate;

upstream raw materials:

4-ethylpiperazine

5-bromo2-nitropyridine

1-ethyl-4-(6-nitropyridin-3-yl)piperazine

5-fluoro-2-nitro-pyridine

Downstream raw materials:

6-tert-Butyl-2-(3-{5-[5-(4-ethyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-8-fluoro-2H-phthalazin-1-one

7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

7-(3,5-dimethoxyphenyl)-N-[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

2-(3-(5-(5-(4-ethylpiperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one

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