(2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate
CAS No.:1378388-37-4
Molecular Formula:C₁₃H₂₃NO₅
Molecular Weight:273.329
Hs Code.:
Mol file:1378388-37-4.mol

Synonyms:(2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Suppliers and Price of (2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 7 raw suppliers

Chemical Property of (2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

There total 1 articles about (2S,4S)-1-tert-butyl 2-methyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1378388-37-4
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 °C

2: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C

3: potassium carbonate / 0 - 20 °C

4: palladium on activated charcoal; hydrogen; magnesium oxide / methanol / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; magnesium oxide; potassium carbonate; Dess-Martin periodane; triethylamine; In methanol; dichloromethane;

Reference yield: 99.0%

: 1378388-37-4
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1378388-16-9
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 1378388-37-4
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1377049-84-7
methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

2: caesium carbonate / 4 h / 20 °C

3: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C

4: caesium carbonate / 20 h / 50 °C

5: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C

6: manganese(IV) oxide / dichloromethane / 13 h

7: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; pyridinium hydrobromide perbromide; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; ammonium acetate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene;