(S)-3-Cyanopiperidine hydrochloride

Base Information

• Chemical Name: (S)-3-Cyanopiperidine hydrochloride
• CAS No.: 915226-72-1
• Molecular Formula: C6H11ClN2
• Molecular Weight: 146.62
• Hs Code.: 2933399990
• Mol file: 915226-72-1.mol

Synonyms:(S)-3-Cyanopiperidine hydrochloride;(3S)-piperidine-3-carbonitrile hydrochloride;(S)-Piperidine-3-carbonitrile hydrochloride

Chemical Property of (S)-3-Cyanopiperidine hydrochloride

Chemical Property:

• PSA: 35.82000
• LogP: 1.64038
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(S)-3-Cyanopiperidinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Cyanopiperidine hydrochloride

There total 3 articles about (S)-3-Cyanopiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (915226-39-0) → (S)-piperidine-3-carbonitrile hydrochloride (915226-72-1,1199773-75-5,1407991-27-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃;

Reference yield:

(S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (88466-77-7) → (S)-piperidine-3-carbonitrile hydrochloride (915226-72-1,1199773-75-5,1407991-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentoxide / pyridine / 0 - 20 °C

2: 1,4-dioxane; dichloromethane / 1.5 h / 0 - 20 °C

With phosphorus pentoxide; In 1,4-dioxane; pyridine; dichloromethane;

Reference yield:

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (88495-54-9) → (S)-piperidine-3-carbonitrile hydrochloride (915226-72-1,1199773-75-5,1407991-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloroformic acid ethyl ester; triethylamine / chloroform / 0.17 h / 0 °C

1.2: 4 h / 20 °C

2.1: phosphorus pentoxide / pyridine / 0 - 20 °C

3.1: 1,4-dioxane; dichloromethane / 1.5 h / 0 - 20 °C

With phosphorus pentoxide; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; pyridine; dichloromethane; chloroform;

upstream raw materials:

(S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

(S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

Downstream raw materials:

(S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine

(S)-1-(4-fluoro-benzoyl)-piperidine-3-carbonitrile

Refernces

• 1、 -. "PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS". Page/Page column 50. . Retrieved 2008/06/13.