4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID

Base Information

• Chemical Name: 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID
• CAS No.: 5333-34-6
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Hs Code.: 2918990090
• Mol file: 5333-34-6.mol

Synonyms:4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTANOIC ACID;4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID

Chemical Property of 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID

Chemical Property:

• Vapor Pressure: 2.92E-08mmHg at 25°C
• Melting Point: 159-161 °C
• Boiling Point: 432.9 °C at 760 mmHg
• PKA: 4.51±0.17(Predicted)
• Flash Point: 167.7 °C
• PSA: 72.83000
• Density: 1.211 g/cm³
• LogP: 1.75130

Purity/Quality:

99% ^*data from raw suppliers

4-(3,4-Dimethoxyphenyl)-4-oxobutyricacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID

There total 13 articles about 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 2-(3,4-dimethoxyphenyl)-2-(morpholin-1-yl)acetonitrile (37673-11-3) → 3-(3,4-dimethoxybenzoyl)propionic acid (5333-34-6)

Guidance literature:

2-(3,4-dimethoxyphenyl)-2-(morpholin-1-yl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

acrylic acid methyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 91.5%

methyl 4-(3,4-dimethoxyphenyl)-4-oxobutanoate (14563-40-7) → 3-(3,4-dimethoxybenzoyl)propionic acid (5333-34-6)

Guidance literature:

With sodium hydroxide; for 0.166667h; Heating;

Reference yield: 89.0%

succinic acid anhydride (108-30-5) + 1,2-dimethoxybenzene (91-16-7) → 3-(3,4-dimethoxybenzoyl)propionic acid (5333-34-6)

Guidance literature:

With aluminum (III) chloride; In nitrobenzene; at 0 - 60 ℃; for 3h;

upstream raw materials:

succinic acid anhydride

1,2-dimethoxybenzene

methyl 4-(3,4-dimethoxyphenyl)-4-oxobutanoate

(Z)-2-(3,4-Dimethoxyphenyl)-2-methoxycyclopropancarbonsaeure

Downstream raw materials:

4-(3,4-Dimethoxybenzoyl)-4,5-dihydro-2(3H)-furanone

4-hydroxymethyl-4-veratroyl-dihydro-furan-2-one

5-(3,4-dimethoxy-phenyl)-3-((Ξ)-piperonylidene)-3H-furan-2-one

4-(3,4-dimethoxyphenyl)butanoic acid