Fluocortolone Acetate

Base Information

• Chemical Name: Fluocortolone Acetate
• CAS No.: 1176-82-5
• Molecular Formula: C24H31FO5
• Molecular Weight: 418.506
• Mol file: 1176-82-5.mol

Synonyms:Fluocortolone Acetate;(6α,11β,16α)-21-(Acetyloxy)-6-fluoro-11- hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione;21-Acetoxy-6α-fluoro-11β-hydroxy-16α-Methylpregna-1,4-diene-3,20-dione;21-Acetoxyfluocortolone

Chemical Property of Fluocortolone Acetate

Chemical Property:

• PSA: 80.67000
• LogP: 3.20750
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

FluocortoloneAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluocortolone (F500500) derivative. Glucocorticoid.

Technology Process of Fluocortolone Acetate

There total 4 articles about Fluocortolone Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl magnesium iodide (917-64-6) + C23H27FO5 → 6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate (1176-82-5)

Guidance literature:

With copper(l) chloride; In tetrahydrofuran; at -10 - -5 ℃; for 2h; Inert atmosphere;

Reference yield:

C21H25FO4 → 6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate (1176-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h / Reflux

2: copper(l) chloride / tetrahydrofuran / 2 h / -10 - -5 °C / Inert atmosphere

With pyridine; copper(l) chloride; In tetrahydrofuran;

Reference yield:

→ 6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate (1176-82-5)

Guidance literature:

Aus 6α-Fluor-11β-hydroxy-21-acetoxy-1,4,16-pregnatrien-3,20-dion, 1.) Lithium-dimethylkupfer, 2.) Ac2O;

upstream raw materials:

methyl magnesium iodide

Downstream raw materials:

fluocortolone