L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-

Base Information

• Chemical Name: L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-
• CAS No.: 865774-79-4
• Molecular Formula: C15H19F2NO2
• Molecular Weight: 283.31
• Mol file: 865774-79-4.mol

Synonyms:L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-;(S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)pentanoicacid

Chemical Property of L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-

Chemical Property:

• PSA: 49.33000
• LogP: 3.05590

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-

There total 6 articles about L-Norvaline, N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C19H27F2NO2 (1309869-67-7) → 2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (865774-79-4)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester (865774-78-3) → 2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (865774-79-4)

Guidance literature:

2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water; pH=7;

Reference yield:

2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester → 2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (865774-84-1) + 2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (865774-79-4)

Guidance literature:

2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water; pH=7;

upstream raw materials:

2-(6,8-difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid methyl ester

6,8-difluoro-3,4-dihydronaphthalen-2(1H)-one

C₁₉H₂₇F₂NO₂

(S)-2-aminopentanoic acid tert-butyl ester

Downstream raw materials:

C₂₄H₃₅F₂N₅O

PF-03084014