2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)

Base Information

Chemical Name:2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)
CAS No.:329041-28-3
Molecular Formula:C8H13NO2
Molecular Weight:155.197
Hs Code.:2934999090
Mol file:329041-28-3.mol

Synonyms:2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)

Suppliers and Price of 2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)

Chemical Property:

PSA：38.33000
LogP:0.62870

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI)

There total 6 articles about 2-Oxa-5-azabicyclo[2.2.2]octan-3-one,8,8-dimethyl-,(1R,4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 329041-27-2
(1R,4R)-8,8-Dimethyl-5-((R)-1-phenyl-ethyl)-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

: 329041-28-3
(1 R ,4 R)-8,8-Dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2005.03.105

Reference yield:

: (1 R ,4 R)-8,8-Dimethyl-5-(1-phenyl-ethyl)-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

: 329041-28-3
(1 R ,4 R)-8,8-Dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 19h; under 2585.81 Torr;

Reference yield:

: 329041-24-9
(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

: 329041-28-3
(1 R ,4 R)-8,8-Dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / DHQD-PHN; K₃Fe(CN)6; K₂CO₃ / 2-methyl-propan-2-ol; H₂O

2: 97 percent / aq. HCl / Heating

3: 78 percent / TsCl; pyridine / 20 °C

4: 36 percent / H₂ / Pd/C / methanol

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; p-toluenesulfonyl chloride; potassium hexacyanoferrate(III); palladium on activated charcoal; In methanol; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.03.105