(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

Base Information

• Chemical Name: (2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile
• CAS No.: 329041-24-9
• Molecular Formula: C₁₆H₂₂N₂
• Molecular Weight: 242.364
• Mol file: 329041-24-9.mol

Synonyms:(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

Chemical Property of (2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile

There total 1 articles about (2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,2-dimethyl-4-pentenal (5497-67-6) + potassium cyanide (151-50-8) + (R)-1-phenylethylamine hydrochloride (10277-86-8) → (2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile (329041-24-9)

Guidance literature:

In methanol;

DOI:10.1016/j.bmcl.2005.03.105

Reference yield: 73.0%

(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile (329041-24-9) → (R)-5,6-Dihydroxy-3,3-dimethyl-2-((R)-1-phenyl-ethylamino)-hexanenitrile

Guidance literature:

With potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; potassium hexacyanoferrate(III); In water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2005.03.105

Reference yield:

(2R)-3,3-dimethyl-2-(1-(R)-phenyl-ethylamino)-hex-5-enenitrile (329041-24-9) → (R,R,R)-5,6-dihydroxy-3,3-dimethyl-2-(1-phenyl-ethylamino)-hexanenitrile (329041-25-0)

Guidance literature:

With potassium osmate(VI); water; potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; potassium hexacyanoferrate(III); tert-butyl alcohol; at 4 ℃; for 64h;

upstream raw materials:

2,2-dimethyl-4-pentenal

potassium cyanide

(R)-1-phenylethylamine hydrochloride

Downstream raw materials:

(1R,4R)-8,8-Dimethyl-5-((R)-1-phenyl-ethyl)-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

(3R,6R)-6-Hydroxymethyl-4,4-dimethyl-3-((R)-1-phenyl-ethylamino)-tetrahydro-pyran-2-one

(1R,4R)-5-(4-hydroxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one

(1 R ,4 R)-5-(4-Benzyloxy-benzenesulfonyl)-8,8-dimethyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one