N4-Acetylsulfapyridine-d4

Base Information

• Chemical Name: N4-Acetylsulfapyridine-d4
• CAS No.: 1189732-52-2
• Molecular Formula: C₁₃H₁₃N₃O₃S
• Molecular Weight: 295.299
• Mol file: 1189732-52-2.mol

Synonyms:4'-(2-PyridylsulfaMoyl)acetanilide-d5;N-[4-[(2-PyridinylaMino)sulfonyl]phenyl-d4]acetaMide;N4-Acetylsulfapyridine-d4;N-Acetyl Sulfapyridine-d4 (Major)

Chemical Property of N4-Acetylsulfapyridine-d4

Chemical Property:

• PSA: 100.03000
• LogP: 3.64410
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

≥99% ^*data from raw suppliers

N-AcetylSulfapyridine-d4(Major) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A major active labelled metabolite related to the adverse effects of Sulfasalazine

Technology Process of N4-Acetylsulfapyridine-d4

There total 5 articles about N4-Acetylsulfapyridine-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminopyridine (504-29-0) + p-acetamidobenzenesulfonyl chloride-d4 (77435-44-0) → C13H9(2)H4N3O3S (1189732-52-2)

Guidance literature:

In pyridine; at 30 - 55 ℃; for 1h;

Reference yield:

aniline-d5 (4165-61-1) → C13H9(2)H4N3O3S (1189732-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; acetic acid / 0.5 h / 30 °C

2: chlorosulfonic acid / 0.33 h / 60 °C

3: pyridine / 1 h / 30 - 55 °C

With chlorosulfonic acid; sodium acetate; acetic acid; In pyridine;

Reference yield:

acetanilide-d5 (15826-91-2) → C13H9(2)H4N3O3S (1189732-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0.33 h / 60 °C

2: pyridine / 1 h / 30 - 55 °C

With chlorosulfonic acid; In pyridine;

upstream raw materials:

aniline-d5

acetanilide-d5

2-aminopyridine

p-acetamidobenzenesulfonyl chloride-d₄

Refernces