tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate
CAS No.:1013333-61-3
Molecular Formula:C20H27NO4
Molecular Weight:345.43268
Hs Code.:2934999090
Mol file:1013333-61-3.mol

Synonyms:tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate;Spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid, 3,4-dihydro-6,7-diMethyl-4-oxo-, 1,1-diMethylethyl ester;tert-Butyl 6,7-dimethyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

Suppliers and Price of tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl6,7-dimethyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate 95+%
1g
$ 1353.00

Chemenu
tert-butyl6,7-dimethyl-4-oxospiro[chromane-2,4''-piperidine]-1''-carboxylate 95%
1g
$ 1274.00

Alichem
tert-Butyl6,7-dimethyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
1g
$ 1126.82

Total 3 raw suppliers

Chemical Property of tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate

Chemical Property:

PSA：55.84000
LogP:3.97620
Storage Temp.:2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

tert-Butyl6,7-dimethyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate

There total 1 articles about tert-butyl 6,7-diMethyl-4- oxo-3,4-dihydro-1η-spiro[chroMene-2,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

: 36436-65-4
2-acetyl-4,5-dimethylphenol

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1013333-61-3
tert-butyl 6,7-dimethyl-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

Guidance literature:: With pyrrolidine; In methanol; for 24h;

Reference yield: 78.6%

: 1013333-61-3
tert-butyl 6,7-dimethyl-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

: 927978-38-9
6,7-dimethylspiro[chromene-2,4-piperidin]-4(3H)-one

Guidance literature:: tert-butyl 6,7-dimethyl-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In water; pH=~ 14;

Reference yield:

: 1013333-61-3
tert-butyl 6,7-dimethyl-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate

: 1031413-43-0
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

1.2: pH ~ 14

2.1: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With triethylamine; HATU; trifluoroacetic acid; In dichloromethane;