Chemical Property of Nobiletin
Chemical Property:
- Vapor Pressure:8.39E-14mmHg at 25°C
- Melting Point:136.0 to 140.0 °C
- Refractive Index:1.558
- Boiling Point:587.9 °C at 760 mmHg
- Flash Point:256.5 °C
- PSA：85.59000
- Density:1.244 g/cm3
- LogP:3.51160
- Storage Temp.:-20°C
- Solubility.:Soluble in DMSO (up to 10 mg/ml)
- XLogP3:3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:7
- Exact Mass:402.13146766
- Heavy Atom Count:29
- Complexity:593
- Purity/Quality:
-
99% *data from raw suppliers
Nobiletin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC
- Recent NIPH Clinical Trials:A study to examine the effects of food intake on relief from eye and nasal discomfort.
-
Description
Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment. Nobiletin (478-01-3) is a natural product isolated from citrus peels.? It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice?via?a?Clock?gene-dependent mechanism.1? Nobiletin directly bound to and activated RORα/γ.? Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
-
Uses
NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. matrix metaloproteinase inhibitor; antineoplastic Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein.
