Technology Process of (4R)-1-Methyl-4-propyl-L-proline Hydrochloride
There total 7 articles about (4R)-1-Methyl-4-propyl-L-proline Hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium on activated carbon; hydrogen;
In
methanol; water;
under 3750.38 Torr;
DOI:10.1039/C9OB00003H
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium; naphthalene / tetrahydrofuran / 2 h / Inert atmosphere; Cooling
1.2: pH 0 - 1
2.1: hydrogen; palladium on activated carbon / methanol; water / 3750.38 Torr
With
naphthalene; palladium on activated carbon; hydrogen; sodium;
In
tetrahydrofuran; methanol; water;
DOI:10.1039/C9OB00003H
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 70 °C / Inert atmosphere
2.1: o-(diphenylphosphino)benzoic acid methyl ether; bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen / dichloromethane / 24 h / 20 °C / 5171.62 Torr
3.1: sodium periodate; ruthenium(III) chloride trihydrate / chloroform; water; acetonitrile / 2 h / 20 °C
4.1: sodium; naphthalene / tetrahydrofuran / 2 h / Inert atmosphere; Cooling
4.2: pH 0 - 1
5.1: hydrogen; palladium on activated carbon / methanol; water / 3750.38 Torr
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; bis(norbornadiene)rhodium(l)tetrafluoroborate; sodium periodate; naphthalene; ruthenium(III) chloride trihydrate; palladium on activated carbon; o-(diphenylphosphino)benzoic acid methyl ether; hydrogen; sodium;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1039/C9OB00003H