4-(3-bromopropyl)-1,2-dichloroBenzene

Base Information

• Chemical Name: 4-(3-bromopropyl)-1,2-dichloroBenzene
• CAS No.: 29648-26-8
• Molecular Formula: C₉H₉BrCl₂
• Molecular Weight: 267.98
• Mol file: 29648-26-8.mol

Synonyms:4-(3-bromopropyl)-1,2-dichloroBenzene

Chemical Property of 4-(3-bromopropyl)-1,2-dichloroBenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-bromopropyl)-1,2-dichloroBenzene

There total 2 articles about 4-(3-bromopropyl)-1,2-dichloroBenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(3 ,4-dichlorophenyl)propan-1-ol (39960-05-9) → 1-bromo-3-(3,4-dichlorophenyl)-propane (29648-26-8)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.9b00946

Reference yield:

3,4-Dichlorocinnamic acid (7312-27-8) → 1-bromo-3-(3,4-dichlorophenyl)-propane (29648-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere; Reflux

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.9b00946

Reference yield: 72.0%

sodium cyanide (773837-37-9) + 1-bromo-3-(3,4-dichlorophenyl)-propane (29648-26-8) → 4-(3,4-dichlorophenyl)butanenitrile (39960-06-0)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃; for 1h;

DOI:10.1021/acs.jmedchem.9b00946

upstream raw materials:

3-(3 ,4-dichlorophenyl)propan-1-ol

3,4-Dichlorocinnamic acid

Downstream raw materials:

4-[3-(3,4-Dichloro-phenyl)-propylamino]-benzoic acid ethyl ester

5-(3,4-Dichloro-phenyl)-2-oxo-pentanoic acid ethyl ester

Ethyl 2-(Benzylamino)-5-(3,4-dichlorophenyl)pentanoate

4-[3-(3,4-Dichloro-phenyl)-propylamino]-benzoic acid