5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 35975-58-7
• Molecular Formula: C₁₂H₉Cl₂NO₃
• Molecular Weight: 286.114
• Hs Code.: 2933499090
• Mol file: 35975-58-7.mol

Synonyms:ETHYL 5,8-DICHLORO-4-HYDROXY-3-QUINOLINECARBOXYLATE;5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 7.95E-07mmHg at 25°C
• Melting Point: 317 - 319 °C (ethanol)
• Boiling Point: 406.7°C at 760 mmHg
• Flash Point: 199.8°C
• PSA: 59.42000
• Density: 1.444g/cm³
• LogP: 3.42390

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL 5,8-DICHLORO-4-HYDROXY-3-QUINOLINECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 6 articles about 5,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NSC137121 (19056-82-7) → 5,8-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (185011-95-4,35975-58-7)

Guidance literature:

With diphenyl ether-biphenyl eutectic; at 250 ℃; for 1h; Yield given;

DOI:10.1002/(SICI)1097-458X(199611)34:11<972::AID-OMR994>3.0.CO;2-9

Reference yield:

2,5 dichloroaniline (95-82-9) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 5,8-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (185011-95-4,35975-58-7)

Guidance literature:

2,5 dichloroaniline; diethyl 2-ethoxymethylenemalonate; at 100 ℃;

In diphenylether; at 250 ℃; for 4h; Reflux;

DOI:10.1039/c9ra10663d

Reference yield:

2,5 dichloroaniline (95-82-9) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 5,8-Dichloro-4-hydroxy-quinoline-3-carboxylic acid ethyl ester (35975-58-7)

Guidance literature:

2,5 dichloroaniline; diethyl 2-ethoxymethylenemalonate; at 100 ℃; for 3h;

In diphenylether; at 250 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.01.018

upstream raw materials:

2,5 dichloroaniline

diethyl 2-ethoxymethylenemalonate

NSC137121

Downstream raw materials:

5,8-dichloro-4-quinolinol-3-carboxylic acid

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