AKOS BB-5220

Base Information

• Chemical Name: AKOS BB-5220
• CAS No.: 157665-24-2
• Molecular Formula: C19H22N2O2
• Molecular Weight: 310.396
• Hs Code.: 2933599090
• Mol file: 157665-24-2.mol

Synonyms:AKOS BB-5220;(4-Benzhydryl-piperazin-1-yl)-acetic acid;2-(4-benzhydrylpiperazin-1-yl)acetic acid

Chemical Property of AKOS BB-5220

Chemical Property:

• PSA: 43.78000
• LogP: 2.35400

Purity/Quality:

98%min ^*data from raw suppliers

(4-Benzhydryl-piperazin-1-yl)-acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BB-5220

There total 6 articles about AKOS BB-5220 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 2-(4-benzylhydrylpiperazin-1-yl)acetate (58103-08-5) → 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid (157665-24-2)

Guidance literature:

With sodium hydroxide; In methanol; Heating;

DOI:10.1248/cpb.42.2276

Reference yield:

(4-Benzhydrylpiperazin-1yl)-acetic acid, methyl ester → 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid (157665-24-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water;

Reference yield:

diphenylmethylpiperazine (841-77-0) → 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid (157665-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / K₂CO₃ / dimethylformamide / 80 °C

2: 93 percent / 2N aq. NaOH / methanol / Heating

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.42.2276

upstream raw materials:

ethyl 2-(4-benzylhydrylpiperazin-1-yl)acetate

diphenylmethylpiperazine

N-benzhydryl-N'-methylpiperazine

1-benzhydryl-4-(ethoxycarbonyl)piperazine

Refernces

• 1、 -. "Glycine transporter-1 inhibitors". Page/Page column 31. . Retrieved 2008/06/13.
• 2、 -. "Imidazopyridine derivatives as dual histamine (H1) and platelet activating factor (PAF) antagonists". . . Retrieved 2008/06/13.