TC-O 9311

Base Information

• Chemical Name: TC-O 9311
• CAS No.: 444932-31-4
• Molecular Formula: C20H19N3O4
• Molecular Weight: 365.389
• Mol file: 444932-31-4.mol

Synonyms:TC-O 9311;2-(3,5-diMethoxybenzoyl)-N-(naphthalen-1-yl)hydrazinecarboxaMide

Chemical Property of TC-O 9311

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

TC-O 9311 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,?5-?Dimethoxybenzoic Acid 2-?[(1-?naphthalenylamino)?carbonyl]?hydrazide is a potent GPR139 agonist.

Technology Process of TC-O 9311

There total 10 articles about TC-O 9311 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,5-dimethoxy-benzoic acid hydrazide (51707-38-1) + 1-Naphthyl isocyanate (86-84-0) → 2-(3,5-dimethoxybenzoyl)-N-(naphthalen-1-yl)hydrazine-1-carboxamide (444932-31-4)

Guidance literature:

In tetrahydrofuran; methanol; for 1.5h;

DOI:10.1039/c5ra21326f

Reference yield:

4-bromo-3,5-dimethoxybenzoic acid (56518-42-4) → 2-(3,5-dimethoxybenzoyl)-N-(naphthalen-1-yl)hydrazine-1-carboxamide (444932-31-4) + C20H18(2)HN3O4

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 16 h / Reflux

2: hydrazine hydrate / ethanol / 8 h / 50 °C

3: tetrahydrofuran; methanol / 1 h

4: palladium on activated charcoal; deuterium / N,N-dimethyl-formamide / 30.5 h / 20 °C

With sulfuric acid; palladium on activated charcoal; hydrazine hydrate; deuterium; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1039/c5ra21326f

Reference yield:

methyl 3,5-dimethoxybenzoate (2150-37-0) → 2-(3,5-dimethoxybenzoyl)-N-(naphthalen-1-yl)hydrazine-1-carboxamide (444932-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 8 h / 55 °C

2: tetrahydrofuran; methanol / 1.5 h

With hydrazine hydrate; In tetrahydrofuran; methanol; ethanol;

DOI:10.1039/c5ra21326f

upstream raw materials:

3,5-dimethoxy-benzoic acid hydrazide

1-Naphthyl isocyanate

C₉H₁₁BrN₂O₃

methyl 3,5-dimethoxybenzoate