26-Hydroxycholest-4-en-3-one

Base Information

Chemical Name:26-Hydroxycholest-4-en-3-one
CAS No.:19257-21-7
Molecular Formula:C₂₇H₄₄O₂
Molecular Weight:400.645
Hs Code.:
DSSTox Substance ID:DTXSID501308608
Metabolomics Workbench ID:62870
Nikkaji Number:J128.834B
Wikidata:Q27104910
Mol file:19257-21-7.mol

Synonyms:26-Hydroxycholest-4-en-3-one;19257-21-7;3-oxocholest-4-en-26-ol;cholest-4-ene-26-ol-3-one;(25xi)-26-hydroxycholest-4-en-3-one;Cholest-4-en-3-one, 26-hydroxy-;hydroxy-4-cholesten-3-one;Cholest-4-en-27-ol-3-one;SCHEMBL1177093;CHEBI:63640;CXUORUGFOXGJNY-XVENTEFESA-N;DTXSID501308608;26-Hydroxycholest-4-en-3-one #;Q27104910;(8S,9S,10R,13R,14S,17R)-17-[(2R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Suppliers and Price of 26-Hydroxycholest-4-en-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 26-Hydroxycholest-4-en-3-one

Chemical Property:

PSA：37.30000
LogP:6.56930
XLogP3:7.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:400.334130642
Heavy Atom Count:29
Complexity:651

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)CO
Isomeric SMILES:C[C@H](CCCC(C)CO)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

Technology Process of 26-Hydroxycholest-4-en-3-one

There total 19 articles about 26-Hydroxycholest-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57984-04-0,71424-84-5,71424-85-6
6β-methoxy-3α,5-cyclo-5α-chol-23-en-22-ol

: 19257-21-7,41530-25-0,56792-59-7
(25ξ)-26-hydroxycholest-4-en-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: 76 percent / propionic acid / xylene / 3 h / Heating

2: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

3: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

4: 98 percent / imidazole / dimethylformamide / 1 h

5: 89 percent / 0.67 h / Heating

6: LAH / diethyl ether / 1 h

7: pyridinium chlorochromate (PCC) / CH₂Cl₂ / 6 h

8: HCl / diethyl ether / 0.75 h / 0 °C

9: TBAF / tetrahydrofuran / 22 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; propionic acid; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; xylene;

Reference yield:

: 137436-15-8
ethyl (25ξ,22E)-6β-methoxy-3α,5-cyclo-5α-cholest-22-en-26-oate

: 19257-21-7,41530-25-0,56792-59-7
(25ξ)-26-hydroxycholest-4-en-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / H₂ / PtO₂ / hexane / 30 h / 760 Torr

2: 6.7 g / LAH / diethyl ether / 0.5 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h

4: 89 percent / 0.67 h / Heating

5: LAH / diethyl ether / 1 h

6: pyridinium chlorochromate (PCC) / CH₂Cl₂ / 6 h

7: HCl / diethyl ether / 0.75 h / 0 °C

8: TBAF / tetrahydrofuran / 22 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;