3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Base Information

• Chemical Name: 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide
• CAS No.: 1235406-40-2
• Molecular Formula: C9H5FN4O2S2
• Molecular Weight: 284.295
• Mol file: 1235406-40-2.mol

Synonyms:3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Chemical Property of 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

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Technology Process of 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

There total 1 articles about 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,3,4-thiadiazol-5-amine (7552-07-0) + 3-cyano-4-fluorobenzene-1-sulfonyl chloride (351003-23-1) → 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235406-40-2)

Guidance literature:

1,3,4-thiadiazol-5-amine; With sodium hydroxide; In 1,4-dioxane; water; for 0.0833333h;

3-cyano-4-fluorobenzene-1-sulfonyl chloride; In 1,4-dioxane; water; at 20 ℃; for 3h;

Reference yield: 91.0%

3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235406-40-2) + tert-butyl 4-(2-(((4-(4-hydroxy-3'-(trifluoromethyl)[1,1'-biphenyl]-3-yl)pyridin-2-yl)methyl)amino)ethyl)piperidine-1-carboxylate → tert-butyl 4-(2-(((4-(4-(4-(N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-2-cyanophenoxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-3-yl)pyridin-2-yl)methyl)amino)ethyl)piperidine-1-carboxylate

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 60 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.09.056

Reference yield: 74.0%

3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (1235406-40-2) + 6'-hydroxy-1,1':3',1-terphenyl-3-carbaldehyde → 3-cyano-4-[(3-formyl-1,1':3',1-terphenyl-4'-yl)oxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 2h;

upstream raw materials:

1,3,4-thiadiazol-5-amine

3-cyano-4-fluorobenzene-1-sulfonyl chloride

Downstream raw materials:

3-cyano-4-(4-fluoro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

3-cyano-4-[(4'-isopropoxy-2'-methylbiphenyl-2-yl)oxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

3-cyano-4-(2-cyclopropyl-4-fluorophenoxy)-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

3-Cyano-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

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