7552-07-0

Basic information

• Product Name: 5-Amino-1,2,4-thiadiazole
• Synonyms: 5-AMINO-1,2,4-THIADIAZOLE;1,2,4-THIADIAZOL-5-AMINE;1,2,4-THIADIAZOL-5-YLAMINE;1,2,4-Thiadiazole, 5-amino-;1,2,4-Thiadiazol-5-amine(9CI);[1,2,4]Thiadiazol-5-ylaMine hydrochloride;[1,2,4]Thiadiazol-5-ylaMine.HCl;1,2,4-Thiadiazole-5-aMine
• CAS NO: 7552-07-0
• Molecular Formula: C₂H₃N₃S
• Molecular Weight: 101.13
• Product Categories: VARIOUSAMINE
• Mol File: 7552-07-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 112-115°C
• Boiling Point: 2.8 °C at 760 mmHg
• Flash Point: 98.3°C
• Appearance: /
• Density: 0.692 g/cm³
• Vapor Pressure: 0.0412mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.97±0.50(Predicted)
• CAS DataBase Reference: 5-Amino-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1,2,4-thiadiazole(7552-07-0)
• EPA Substance Registry System: 5-Amino-1,2,4-thiadiazole(7552-07-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/22
• Safety Statements: S22:Do not inhale dust.; S36/37:Wear suitable protective clothing and gloves.
• HazardClass: IRRITANT
• Hazardous Substances Data: 7552-07-0(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

5-Amino-1,2,4-thiadiazole is a useful research chemical for organic synthesis and other chemical processes.

InChI:InChI=1/C2H3N3S/c3-2-4-1-5-6-2/h1H,(H2,3,4,5)

Upstream product

• 115948-81-7 N-chloro-formamidine 
• 333-20-0 potassium thioacyanate 
• 6313-33-3 formamidine hydrochloride 
• 67-56-1 methanol 
• 7726-95-6 bromine 
• 463-52-5 formamidine 
• 152513-91-2 5-amino-1,2,4-thiadiazole hydrochloride 
• 3473-63-0 formamidine acetic acid 
• 943653-32-5 2-amino-4-dimethylamino-1,3-thiazabuta-1,3-diene 

Downstream Products

• 38362-15-1 5-chloro-1,2,4-thiadiazole 
• 94863-56-6 [1,2,4]thiadiazol-5-yl-trityl-amine 
• 91344-35-3 C-phenyl-N,N'-bis-[1,2,4]thiadiazol-5-yl-methanediamine 
• 90323-42-5 benzylidene-[1,2,4]thiadiazol-5-yl-amine 
• 63682-70-2 5-methyl-6-phenyl-imidazo[1,2-d][1,2,4]thiadiazole 
• 103274-67-5 5-(2,4-dimethyl-phenylazo)-[1,2,4]thiadiazole 
• 63682-63-3 2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-phenyl-ethanone 
• 63682-65-5 2-(5-imino-[1,2,4]thiadiazol-4-yl)-1-(4-methoxy-phenyl)-ethanone 
• 103907-06-8 5-(2,4,6-trimethyl-phenylazo)-[1,2,4]thiadiazole 
• 1079394-32-3 4-(4-(1,2,4-thiadiazol-5-ylamino)-6-chloropyrimidin-2-ylthio)-N-(2,2,2-trifluoroethyl)benzamide 
• 1208552-71-9 C₁₃H₁₄ClN₃OS 
• 1362689-36-8 N-(3-(4-fluorophenylsulfonyl)isoquinolin-1-yl)-1,2,4-thiadiazol-5-amine 

Relevant articles and documents

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

The discovery and selection of a highly potent and selective NaV1.7 inhibitor PF-06456384, designed specifically for intravenous infusion, is disclosed. Extensive in vitro pharmacology and ADME profiling followed by in vivo preclinical PK and efficacy model data are discussed. A proposed protein–ligand binding mode for this compound is also provided to rationalise the high levels of potency and selectivity over inhibition of related sodium channels. To further support the proposed binding mode, potent conjugates are described which illustrate the potential for development of chemical probes to enable further target evaluation.

HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

2-amino-4-dimethylamino-1-thia-3-azabutadienes as precursors of thiazoles

The reaction of 2-amino-4-dimethylamino-1-thia-3-azabutadienes 1 with α-bromoketones gave rise to 2-aminothiazoles 2 together with 2-(N,N-dimethylaminomethylenamino)thiazoles 3. Competitive mechanisms are described. Furthermore, reaction of diene 1a with