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Technology Process of SILDENAFIL N-OXIDE

SILDENAFIL N-OXIDE

Base Information
  • Chemical Name:SILDENAFIL N-OXIDE
  • CAS No.:1094598-75-0
  • Molecular Formula:C22H30N6O5S
  • Molecular Weight:490.583
  • Hs Code.:
  • Mol file:1094598-75-0.mol
SILDENAFIL N-OXIDE

Synonyms:SILDENAFIL N-OXIDE;5-[2-Ethoxy-5-[(4-Methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one;Sildenafil EP IMpurity B;Sildenafil impurity B

Suppliers and Price of SILDENAFIL N-OXIDE
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • SildenafilN-Oxide
  • 250mg
  • $ 550.00
  • TRC
  • SildenafilN-Oxide
  • 50mg
  • $ 180.00
  • TRC
  • SildenafilN-Oxide
  • 500mg
  • $ 900.00
  • Medical Isotopes, Inc.
  • SildenafilN-Oxide
  • 50 mg
  • $ 650.00
  • Medical Isotopes, Inc.
  • SildenafilN-Oxide
  • 500 mg
  • $ 2200.00
  • Chemenu
  • 4-((4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)sulfonyl)-1-methylpiperazine1-oxide 95%
  • 1g
  • $ 1370.00
  • Chemenu
  • 4-((4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)sulfonyl)-1-methylpiperazine1-oxide 95%
  • 50mg
  • $ 239.00
  • American Custom Chemicals Corporation
  • SILDENAFIL EP IMPURITY B 95.00%
  • 5MG
  • $ 454.73
Total 20 raw suppliers
Chemical Property of SILDENAFIL N-OXIDE
Chemical Property:
  • PKA:4.57±0.20(Predicted) 
  • PSA：147.99000 
  • LogP:2.60100 
  • Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere 
  • Solubility.:Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly) 
Purity/Quality:

99%, *data from raw suppliers

SildenafilN-Oxide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Uses Sildenafil N-Oxide is an impurity of Sildenafil citrate (S435000), as prodrug. Sildenafil N-Oxide (Sildenafil EP Impurity B) is an impurity of Sildenafil citrate (S435000), as prodrug.
Technology Process of SILDENAFIL N-OXIDE

There total 1 articles about SILDENAFIL N-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

viagra
139755-83-2

viagra

1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-4-oxido-piperazine
1094598-75-0

1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-4-oxido-piperazine

Guidance literature:
viagra; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at -10 ℃; for 2.5h;
With potassium carbonate; In dichloromethane; water; at 0 ℃; for 0.5h;
upstream raw materials:

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