An orally active selective type 5 cGMP phosphodiesterase inhibitor.
ChEBI: A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.
Indications and Usage
Sildenafil Citrate is an oral drug used to treat male erectile dysfunction and is a 5-phosphodiesterase inhibitor developed by the American Pfizer Pharmaceuticals to originally treat cardiovascular disease that was later discovered to improve patients’ sex lives. Sildenafil Citrate treats erectile dysfunction and was the first clinical oral drug used to specifically target male erectile dysfunction.
Common adverse reactions include headache, dizziness, facial flushing, indigestion, nasal congestion, and sight abnormalities, which may be expressed as difficulty differentiation blue/green colors, light sensitivity, or blurry vision. More severe adverse effects include decreased supine blood pressure and decreased cardiac output. Additionally, clinical research shows that engaging in sexual activity after taking Sildenafil Citrate increases the risk of heart abnormalities, including angina pectoris, dizziness, nausea, and other symptoms, and it may also cause sudden cardiac death.