N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide

Base Information

Chemical Name:N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide
CAS No.:1256488-36-4
Molecular Formula:C26H26N2O6S
Molecular Weight:494.568
Hs Code.:
Mol file:1256488-36-4.mol

Synonyms:N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide

Suppliers and Price of N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide

Chemical Property:

PSA：126.85000
LogP:5.64670

Purity/Quality:: 97% or 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide

There total 12 articles about N-[3-[3-tert-Butyl-2-Methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochroMen-7-yl]MethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1256488-83-1
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

: 1256488-36-4
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxoisochromen-7-yl]methanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 75 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm401266k

Reference yield:

: 1256488-81-9
methyl 2-[2-[5-(2-benzyloxy-3-pyridyl)-3-tert-butyl-2-methoxyphenyl]ethynyl]-5-[bis(methylsulfonyl)amino]benzoate

: 1256488-36-4
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxoisochromen-7-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; gold(III) chloride / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 75 °C / Inert atmosphere

With gold(III) chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm401266k

Reference yield:

: 417715-87-8
5-bromo-3-tert-butyl-2-methoxybenzaldehyde

: 1256488-36-4
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxoisochromen-7-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

2: sodium methylate / methanol / 18 h / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 75 °C / Inert atmosphere

4: trifluoroacetic acid; gold(III) chloride / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 75 °C / Inert atmosphere

With gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401266k