N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

Base Information

Chemical Name:N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide
CAS No.:1256488-83-1
Molecular Formula:C₂₇H₂₈N₂O₈S₂
Molecular Weight:572.66
Hs Code.:

Synonyms:N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

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Chemical Property of N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

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Technology Process of N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

There total 11 articles about N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1256488-81-9
methyl 2-[2-[5-(2-benzyloxy-3-pyridyl)-3-tert-butyl-2-methoxyphenyl]ethynyl]-5-[bis(methylsulfonyl)amino]benzoate

: 1256488-83-1
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

Guidance literature:: With gold(III) chloride; trifluoroacetic acid; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm401266k

Reference yield:

: 417715-87-8
5-bromo-3-tert-butyl-2-methoxybenzaldehyde

: 1256488-83-1
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

2: sodium methylate / methanol / 18 h / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 75 °C / Inert atmosphere

4: trifluoroacetic acid; gold(III) chloride / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401266k

Reference yield:

: 1206774-29-9
5-(2-benzyloxy-3-pyridyl)-3-tert-butyl-2-methoxybenzaldehyde

: 1256488-83-1
N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 18 h / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 75 °C / Inert atmosphere

3: trifluoroacetic acid; gold(III) chloride / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401266k