(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL

Base Information

• Chemical Name: (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL
• CAS No.: 911218-03-6
• Molecular Formula: C₈H₈ClFO
• Molecular Weight: 174.602
• Mol file: 911218-03-6.mol

Synonyms:(1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL;(S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL;(αS)-2-Chloro-4-fluoro-α-Methyl-benzeneMethanol

Chemical Property of (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL

Chemical Property:

• PSA: 20.23000
• LogP: 2.53240

Purity/Quality:

99% ^*data from raw suppliers

(αS)-2-Chloro-4-fluoro-α-methyl-benzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (αS)-2-Chloro-4-fluoro-α-methyl-benzenemethanol is a useful synthetic intermediate. It can be prepared using enviro-friendly reagents such as baker''s yeast (BY).

Technology Process of (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL

There total 6 articles about (1S)-1-(2-CHLORO-4-FLUOROPHENYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.81%

2'-chloro-4'-fluoroacetophenone (700-35-6) → 1-(2-chloro-4-fluorophenyl)ethan-1-ol (112108-68-6,911218-03-6)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 15 ℃; for 3h;

Reference yield: 51.0%

2'-chloro-4'-fluoroacetophenone (700-35-6) → (S)-1-(2-Chloro-4-fluoro-phenyl)-ethanol (911218-03-6)

Guidance literature:

With formic acid; C₂₀H₂₃ClIrNO₃; isopropylamine; In dichloromethane; at 20 ℃; enantioselective reaction;

DOI:10.1021/acscatal.8b02068

Reference yield:

2-chloro-4-fluorobenzaldehyde (84194-36-5) → 1-(2-chloro-4-fluorophenyl)ethan-1-ol (112108-68-6,911218-03-6)

Guidance literature:

With methylmagnesium bromide; In diethyl ether;

upstream raw materials:

2'-chloro-4'-fluoroacetophenone

2-chloro-4-fluorobenzaldehyde

methylmagnesium bromide

2-choro-4-fluorobenzoic acid

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