1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one

Base Information

Chemical Name:1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one
CAS No.:1361968-52-6
Molecular Formula:C15H12F3NO2
Molecular Weight:295.2564896
Hs Code.:
Mol file:1361968-52-6.mol

Synonyms:1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one

Suppliers and Price of 1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one

There total 4 articles about 1-(6-(4-(trifluoroMethoxy)phenyl)pyridin-3-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 871250-36-1
1-(6-(4-(trifluoromethyl)phenyl)pyridin-3-yl)propan-1-ol

: 1361968-52-6
1-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-1-one

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201184h

Reference yield:

: 356058-14-5
6-(4-(trifluoromethyl)phenyl)nicotinaldehyde

: 1361968-52-6
1-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

With pyridinium chlorochromate; In diethyl ether; dichloromethane;
DOI:10.1021/jm201184h

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1361968-52-6
1-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm201184h